JMJD3 Antibody (KDM6B)

• Catalog number
  F40552-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  JMJD3 (KDM6B)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the JMJD3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This JMJD3 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q5NCY0
• Purity
  Purified
• Description
  Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
• Immunogen
  A portion of amino acids 954-987 from the mouse protein was used as the immunogen for this JMJD3 antibody.
• Storage
  Aliquot the JMJD3 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  JMJD3   KDM6B  
• Gene symbol
  KDM6B
• Short name
  Anti-JMJD3 (KDM6B)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to JMJD3 (KDM6B)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:29012
• Gene
  KDM6B
• Long gene name
  lysine demethylase 6B
• Synonyms gene
  • JMJD3
• Synonyms gene name
  • jumonji domain containing 3
  • jumonji domain containing 3, histone lysine demethylase
  • lysine (K)-specific demethylase 6B
• Synonyms
  • KIAA0346
• GenBank acession
  • AB002344
• Locus
  17p13.1
• Discovery year
  2004-02-27
• Entrez gene record
  23135
• Pubmed identfication
  • 10662545
  • 9205841
• RefSeq identity
  • NM_001080424
• Classification
  • Lysine demethylases
• VEGA ID
  OTTHUMG00000178021

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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