KCNQ1 Antibody

• Catalog number
  A00310-1
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  KCNQ1
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, mouse, rat
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence in the middle region of human KCNQ1 (356-397aa QQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIR), different from the related mouse sequence by two amino acids, and from the related rat sequence by one amino acid.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the KCNQ1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The KCNQ1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Kv7.1 (KvLQT1) is a potassium channel protein whose primary subunit in humans is encoded by the KCNQ1 gene. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. And this gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.
• Related articles
  1. "Entrez Gene: KCNQ1 potassium voltage-gated channel, KQT-like subfamily, member 1". 2. Jespersen T, Grunnet M, Olesen SP (2005). "The KCNQ1 potassium channel: from gene to physiological function". Physiology (Bethesda). 20 (6): 408–16. 3. Torekov SS, Iepsen E, Christiansen M, Linneberg A, Pedersen O, Holst JJ, Kanters JK, Hansen T (2014). "KCNQ1 Long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia.)". Diabetes. 63 (4): 1315–25.
• Gene Name
  KCNQ1
• Protein Name
  Potassium voltage-gated channel subfamily KQT member 1
• Gene Full Name
  potassium voltage-gated channel subfamily Q member 1
• Synonyms
  ATFB1 | ATFB3 | JLNS1 | KCNA8 | KCNA9 | KCNQ1 | Kv1.9 | Kv7.1 | KVLQT1 | LQT | LQT1 | RWS | SQT2 | WRS | P51787
• Uniprot ID
  P51787
• Entrez GeneID
  3784
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  KCNQ1  
• Gene symbol
  KCNQ1-AS1, KCNQ1OT1, KCNQ1
• Short name
  KCNQ1 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  KCNQ1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:42790
• Gene
  KCNQ1-AS1
• Long gene name
  KCNQ1 antisense RNA 1
• Synonyms gene name
  • KCNQ1 antisense RNA 1 (non-protein coding)
• GenBank acession
  • AJ251642
• Locus
  11p15.4
• Discovery year
  2011-08-19
• Entrez gene record
  338653
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000011704

Gene info

• Identity
  HGNC:6295
• Gene
  KCNQ1OT1
• Long gene name
  KCNQ1 opposite strand/antisense transcript 1
• Synonyms gene name
  • KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)
• Synonyms
  • KvDMR1
  • KCNQ1-AS2
  • KvLQT1-AS
  • LIT1
  • NCRNA00012
• Synonyms name
  • non-protein coding RNA 12
  • KCNQ1 antisense RNA 2 (non-protein coding)
  • KCNQ1 overlapping transcript 1 (non-protein coding)
• Locus
  11p15.5
• Discovery year
  1999-08-05
• Entrez gene record
  10984
• Pubmed identfication
  • 10220444
  • 12772698
• RefSeq identity
  • NR_002728
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000171022
• Locus Specific Databases
  • LRG_1052

Gene info

• Identity
  HGNC:6294
• Gene
  KCNQ1
• Long gene name
  potassium voltage-gated channel subfamily Q member 1
• Synonyms gene
  • LQT
  • KCNA9
• Synonyms gene name
  • potassium voltage-gated channel, KQT-like subfamily, member 1
  • potassium channel, voltage gated KQT-like subfamily Q, member 1
• Synonyms
  • Kv7.1
  • KCNA8
  • KVLQT1
  • JLNS1
  • LQT1
• Synonyms name
  • Jervell and Lange-Nielsen syndrome 1
• GenBank acession
  • AF000571
• Locus
  11p15.5-p15.4
• Discovery year
  1997-02-05
• Entrez gene record
  3784
• Pubmed identfication
  • 8528244
  • 16382104
• RefSeq identity
  • NM_000218
• Classification
  • Potassium voltage-gated channels
• VEGA ID
  OTTHUMG00000009900
• Locus Specific Databases
  • Gene Connection for the Heart
  • KCNQ1 database at LOVD-China
  • CCHMC-BMI & UC Hearing Loss Mutation Database
  • LRG_287

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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