KCNJ5 Antibody ALEXA FLUOR
KCNJ5 Antibody ALEXA FLUOR is available 5 times from Bioss primary conjugated antibodies. alexa fluor labs
- CategoryConjugated Primary Antibodies
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenKCNJ5
- SpecificityThis is a highly specific antibody against KCNJ5.
- Modification SiteNone
- ClonePolyclonal antibody
- Concentration1ug per 1ul
- Subcellular locationExtracellular
- SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human KCNJ5
- Gene ID Number3762
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- CrossreactivityHuman, Mouse, Rat
- Cross-reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Background of the antigenPotassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008].
- PurificationPurified by Protein A.
- Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
- Synonymsinwardly rectying subfamily J member 5; Cardiac ATP sensitive potassium channel; Cardiac inward rectier; CIR; G protein activated inward rectier potassium channel 4; G protein-activated inward rectier potassium channel 4; GIRK 4; GIRK-4; GIRK4; Heart KATP channel; Inward rectier K+ channel Kir3.4; Inward rectier K+ channel KIR3.4; IRK-4; IRK5_HUMAN; KATP 1; KATP-1; KATP1; KCNJ 5; Kcnj5; KIR 3.4; KIR3.4; Potassium channel; Potassium channel inwardly rectying subfamily J member 5; Potassium inwardly rectying channel J5; Potassium inwardly rectying channel subfamily J member 5.
- Gene target
- Short nameKCNJ5 Antibody,
- Alternative techniqueantibodies
bs-9931R-A350 | KCNJ5 Antibody, ALEXA FLUOR 350size: 100ul | 410.81 USD
bs-9931R-A488 | KCNJ5 Antibody, ALEXA FLUOR 488size: 100ul | 410.81 USD
bs-9931R-A555 | KCNJ5 Antibody, ALEXA FLUOR 555size: 100ul | 410.81 USD
bs-9931R-A594 | KCNJ5 Antibody, ALEXA FLUOR 594size: 100ul | 410.81 USD
- Catalog numberbs-9931R-A594
- Price410.81 USD
1. Gene info
- Long gene namepotassium voltage-gated channel subfamily J member 5
- Synonyms gene name
- potassium inwardly-rectifying channel, subfamily J, member 5
- GenBank acession
- Discovery year1995-04-13
- Entrez gene record
- Pubmed identfication
- RefSeq identity
- Potassium voltage-gated channel subfamily J
- Havana BLAST/BLAT
- Locus Specific Databases
- ConceptScope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
- Tree numbers
- Qualifiersclassification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
- PubMedEither of two somatic KCNJ5 mutations are highly prevalent and specific for aldosterone producing lesionsAldosterone-producing adenoma patients with the somatic KCNJ5 mutations showed a higher production of aldosterone than those without such mutations, which translates in a higher lateralization index.Mutations in the KCNJ5 gene, which encodes the GIRK4 K+ channel, have been shown to be responsible for familial hyperaldosteronism type III and a consistent proportion of sporadic aldosterone-producing adenomas. [Review]Kir3.4 potassium channel is expressed in the zona glomerulosa cell membrane and regulates aldosterone biosynthesis[review].Findings in a large Australian cohort show that patients with mutations in KCNJ5 present earlier with the signs and symptoms of primary hyperaldosteronism and benefit from surgical intervention.Biased transmission of the same haplotypes for TS and ADHD was identified in independent samples, supporting this gene as a possible susceptibility locus for both disorders.Different mutations (KCNJ5, ATP1A1, ATP2B3, and CACNA1D) are found in different aldosterone-producing nodules from the same adrenal, suggesting that somatic mutations are independent events triggered by mechanisms that remain to be identified.KCNJ5 mutations in aldosterone-producing adenomas are more frequent in women; however, this gender dimorphism is a reported phenomenon of Western but not East Asian populations (review).
- Gene ontology - Biological process
- Gene ontology - Cellular component
- Gene ontology - Molecular functionvoltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
- Entrez Gene
bs-9931R-A647 | KCNJ5 Antibody, ALEXA FLUOR 647size: 100ul | 410.81 USD
Supplier:Bioss Primary Conjugated Antibodies. ALEXA FLUOR