-
Target antigen
KCNH2
-
Clonality
Polyclonal antibody
-
Clone
Polyclonal antibody
-
Raised in
rabbit
-
Type of the antibody
IgG polyclonal antibody
-
Product form
freeze-dried
-
Reacts with species
human, rat
-
Analyses
WB
-
Immunogen
E.coli-derived human KCNH2 recombinant protein (Position: L856-S1159). Human KCNH2 shares 92% amino acid (aa) sequence identity with both mouse and rat KCNH2.
-
Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
-
Purification
Immunogen affinity purified.
-
Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
-
Storage condtions
Keep the KCNH2 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
-
Tips
The KCNH2 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
-
Background
KCNH2, also known as HERG or KV11.1, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel. It is mapped to 7q36.1. KCNH2 forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K+) ions out of the muscle cells of the heart (cardiac myocytes), and this current is critical in correctly timing the return to the resting state (repolarization) of the cell membrane during the cardiac action potential. What’s more, KCNH2 channels show gating properties consistent with many of the outwardly rectifying potassium channels, but they also have an inactivation mechanism that attenuates efflux during depolarization.
-
Related articles
1. Gianulis, E. C., Trudeau, M. C. Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-a-go-go-related gene potassium channels. J. Biol. Chem. 286: 22160-22169, 2011. 2. Hedley PL; Jorgensen P; Schlamowitz S; Wangari, Romilda et al. (2009). "The genetic basis of long QT and short QT syndromes: a mutation update". Human Mutation 30 (11): 1486–511. 3. Thomas, P. J., Qu, B.-H., Pedersen, P. L. Defective protein folding as a basis of human disease. Trends Biochem. Sci. 20: 456-459, 1995.
-
Gene Name
KCNH2
-
Protein Name
Potassium voltage-gated channel subfamily H member 2
-
Gene Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 2
-
Synonyms
eag homolog antibody|Eag-related protein 1 antibody|ERG antibody|ERG-1 antibody|ERG1 antibody|Ether a go go related potassium channel protein antibody|Ether-a-go-go-related gene potassium channel 1 antibody|Ether-a-go-go-related protein 1 antibody|H ERG antibody|H-ERG antibody|HERG 1 antibody|HERG antibody|hERG-1 antibody|HERG1 antibody|KCNH2 antibody|KCNH2_HUMAN antibody|Kv11.1 antibody|LQT 2 antibody|LQT2 antibody|Potassium channel HERG antibody|Potassium voltage gated channel subfamily H (eag related) member 2 antibody|Potassium voltage-gated channel subfamily H member 2 antibody|SQT1 antibody|Voltage gated potassium channel, subfamily H, member 2 antibody|Voltage-gated potassium channel subunit Kv11.1 antibody|Voltagegated potassium channel, subfamily H, member 2 antibody
-
Uniprot ID
Q12809
-
Entrez GeneID
3757
-
Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translation
anticorps
