K63-linked Tri-Ubiquitin

  • Catalog number
    6419-50
  • Price
    Please ask
  • Size
    50 ug
  • Synonyms
    K63-linked Tri-Ubiquitin
  • Description
    Substrate for defined length polyubiquitination
  • Purity by SDS PAGE
    ≥95%
  • Assay
    Western Blot
  • Molecular Weight
    25.686 kDa (Band migrates faster on gels)
  • Storage Temp
    -80°C
  • Shipping
    Dry ice
  • Shelf Life
    12 months
  • Concentration
    2.5 mg/ml
  • Appearance
    Liquid
  • Physical form description
    2.5 mg/ml in 20 mM Tris-HCl, pH 7.5, 0.15 M NaCl and 1 mM EDTA.
  • Background Information
    Poly-ubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. Modification of proteins by K63-linked polyubiquitination has been implicated in, among other cellular processes, the regulation of the DNA damage response, endosomal sorting, autophagy of misfolded/aggregated proteins, and neurodegeneration. These tri-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 63. The most distal ubiquitin contains an arginine substitution for a lysine at position 63, limiting chain length.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
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