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Stock availabilitIn Stock
In Stock
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CAS number
99570-78-2
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Description
Kinase inhibitor
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Molecular weight
453,5 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
(9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C26H19N3O5
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Origin
Synthetic
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Purity pourcentage
≥98% (HPLC)
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Soluble in
Soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml)
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Physical appearance
White solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Flammable liquids (Category 4), H227 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H227 Combustible liquid Precautionary statements: P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol - resistant foam for extinction. P403 + P235 Store in a well - ventilated place. Keep cool. P501 Dispose of contents/ container to an approved waste disposal plant
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PubChem number
9981344
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Scientific context
K252B is a non-selective, protein kinase inhibitor. It inhibits CaMKII, MYLK, PKA, PKC, and cGKI. It acts by binding to the ATP binding domain of the kinase. K252B is cell permeable.
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Bibliography
1. Nakanishi S., Matsuda Y., Iwahashi K., & Kase H. (1986) J. Antibiotics 39(8): 1066–1071. 2. Teshima R., et al. (1997) J. Immun. 159(2): 964–969. 3. Knüsel B., et al. (1992) J. Neurochem. 59(2): 715–722.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of K252B (SIH-456), a Kinase inhibitor (pan-specific). CAS #: 99570-78-2. Molecular Formula: C26H19N3O5. Molecular Weight: 453.5 g/mol. Chemical structure of K252B, a Kinase inhibitor (pan-specific) (SIH-456). CAS # 99570-78-2. Molecular Formula: C26H19N3O5.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.0001
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
