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Other name
Junction plakoglobin,Catenin gamma,Desmoplakin III,Desmoplakin-3,CTNNG, DP3,JUP
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Immunogen
Recombinant human Junction plakoglobin protein (1-131AA)
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Verified reactivity
Human
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Verified applications
ELISA,WB,IHC. Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
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Raised in
Rabbit
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Clonality
Polyclonal
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Protein number
P14923
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Gene number
Please refer to GenBank
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NCBI number
Please refer to NCBI
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Purity
Caprylic Acid Ammonium Sulfate Precipitation Purified
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Storage recommendation
Aliquot and store at -20°C. Minimize freezing and thawing.
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Use before
1 year
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Shipping requirements
Blue ice
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Estimated production time
3-7 business days
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Supplementary information
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
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Notes
For research use only. Not for diagnostic procedures.
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Properties
If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Group
Polyclonals and antibodies
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About
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
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French translation
anticorps
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Gene target
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Gene symbol
JUP
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Short name
JUP Polyclonal Antibody
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Technique
Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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Label
Unconjugated
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Alternative name
junction plakoglobin polyclonal (antibody to-)
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Alternative technique
polyclonals, antibodies
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Alternative to gene target
junction plakoglobin, ARVD12 and CTNNG and DP3 and DPIII and PDGB and PKGB, JUP and IDBG-49784 and ENSG00000173801 and 3728, cadherin binding, nuclei, Jup and IDBG-211364 and ENSMUSG00000001552 and 16480, JUP and IDBG-640020 and ENSBTAG00000017685 and 445543
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