Jak3 Tyr980 Tyr981 Antibody ALEXA FLUOR

Jak3 Tyr980 Tyr981 Antibody ALEXA FLUOR is available 5 times from Bioss primary conjugated antibodies. alexa fluor labs

bs-3208R-A350 | Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 350size: 100ul | 412.23 USD

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bs-3208R-A488 | Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 488size: 100ul | 412.23 USD

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bs-3208R-A555 | Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 555size: 100ul | 412.23 USD

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bs-3208R-A594 | Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 594size: 100ul | 412.23 USD

  • Long name
    Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 594 Conjugated
  • Also known as
    Anti-Jak3 Tyr980 + Tyr981 PAb ALEXA FLUOR 594
  • Conjugated with
    ALEXA FLUOR® 594
  • Excitation emission
    590nm/617nm
  • Properties
    For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Conjugation
    Alexa Fluor,ALEXA FLUOR® 594
  • Conjugated
    Alexa conjugate 1
  • French translation
    anticorps
  • Label
    ALEXA FLUOR 594
  • Alternative name
    Janus kinase 3 (Tyr980 and Tyr981) (Antibody to), ALEXA FLUOR 594
MeSH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
Product images

bs-3208R-A647 | Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 647size: 100ul | 412.23 USD

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  • Category
    Conjugated Primary Antibodies
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    Jak3 Tyr980 + Tyr981
  • Specificity
    This is a highly specific antibody against Jak3 Tyr980 + Tyr981.
  • Modification
    Phosphorylation
  • Modification Site
    Tyr980 + Tyr981
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Immunogen range
    971-990/1124
  • Subcellular location
    Cytoplasm, Cell membrane
  • Source
    KLH conjugated synthetic phosphopeptide derived from human Jak3 around the phosphorylation site of Tyr980/981
  • Gene ID Number
    3718
  • Swiss Prot
    P52333
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Cross-reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen
    Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
  • Purification
    Purified by Protein A.
  • Storage conditions
    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Synonyms
    JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN; Tyrosine-protein kinase JAK3; Janus kinase 3; Leukocyte janus kinase; JAK3
  • Gene target
  • Short name
    Jak3 (Tyr980 + Tyr981) Antibody,
  • Technique
    Antibody
  • Alternative technique
    antibodies
  • Alternative to gene target
    Janus kinase 3, JAK-3 and JAK3_HUMAN and JAKL and L-JAK and LJAK, JAK3 and IDBG-37201 and ENSG00000105639 and 3718, transferase activity, Plasma membranes, Jak3 and IDBG-166648 and ENSMUSG00000031805 and 16453, BT.44422 and IDBG-641863 and ENSBTAG00000020904 and 538276
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