Ivabradine Hydrochloride

Alternative_name

3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one, monohydrochloride
Description

Ivabradine hydrochloride is a highly selective open channel blocker that targets the mixed Na⁺/K⁺ inward “funny current” (If) carried by hyperpolarization-activated cyclic nucleotide gated (HCN) channels. It has antianginal activity. It lowers heart rate and reduces myocardial oxygen demand.
CAS Number

148849-67-6
Structure Available

Yes
Molecular Formula

C₂₇H₃₆N₂O₅·HCl
Molecular Weight

505.1
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

H₂O (~ 5mg/ml on warming)
Handling

Protect from air and moisture
Tag Line

A highly selective open channel blocker
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
MDL Number

MFCD00929899
PubChem CID

3045381
PubChem CID Link
SMILES

CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC.Cl
InChi

InChI=1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1
InChi Key

HLUKNZUABFFNQS-ZMBIFBSDSA-N
Data Sheet Link
MSDS Available

Yes