ITD 1 for cell activation

ITD 1 for cell activation is available 2 times from Biovision labs

  • Description
    ITD-1 is a potent and highly selective TGFβ pathway inhibitor (IC₅₀ = 0.85 µM). ITD-1 promotes cardiomyocyte differentiation specifically via degradation of the TGFβ type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC₅₀ =  0.4–0.8 µM), revealing a role for TGFβ signaling mechanism as a repressor of cardiomyocyte fate. ITD-1 does not induce differentiation of vascular smooth muscle cells or endothelial cells.
  • Peptide sequence
    N/A
  • CAS number
    1099644-42-4
  • Molecular weight
    415.52
  • Category
    Biochemicals
  • Other name
    4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester
  • Molecular formula
    C₂₇H₂₉NO₃
  • Physical appearance
    Off-white solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    ≥98% by HPLC
  • Reconstitute instructions
    DMSO (~8 mg/ml) or EtOH (~4 mg/ml with warming)
  • Storage condition
    -20°C
  • Shipping condition
    gel pack
  • Maximum time for storage
    36 months
  • Storage instructions
    Protect from air and light
  • Tissue
    cell
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    ITD-1 for activation
  • Technique
    activation
  • Alternative name
    ITD-1 to measure cellular activation

2879-50 | ITD-1 for cell activationsize: 50 mg | 737.86 USD

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2879-10 | ITD-1 for cell activationsize: 10 mg | 230 USD

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