Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt

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Cas number

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Chemical s molecular weight

309.23
Chemical s main applications

Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt is an impurity of Sofosbuvir (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
Chemical s category

Aromatics, Amines, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Other name

N-(Hydroxyphenoxyphosphinyl)-L-alanine 1-Methylethyl Ester Sodium Salt; (2S)-Isopropyl 2-((Hydroxy(phenoxy)phosphoryl)amino)propanoate Sodium Salt
Chemical s formula

C12H17NNaO5P
Physical properties

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Melting temperature

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Boiling temperature

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Chemical s soluble in

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Chemical s specifications