Integrin linked ILK Antibody
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Catalog number
PB9949
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Price
Please ask
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Size
0,1 mg
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Target antigen
Integrin linked ILK
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human
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Analyses
WB
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Immunogen
E.coli-derived human Integrin linked ILK recombinant protein (Position: M1-H203). Human Integrin linked ILK shares 99.5% amino acid (aa) sequence identity with both mouse and rat Integrin linked ILK.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Integrin linked ILK Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Integrin linked ILK Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
ILK, also known as Integrin-linked kinase, is a serine-threonine protein kinase. Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK) interacts with the cytoplasmic domain of beta-1 integrin. This gene was initially described to encode a serine/ threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. Recent results showed that ILK contains 5 ankyrin-like repeats, and that the C-terminal kinase domain is actually a pseudo-kinase with adaptor function.
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Related articles
1. "Entrez Gene: ILK integrin-linked kinase". 2. Fielding AB, Dobreva I, McDonald PC, Foster LJ, Dedhar S (Feb 2008). "Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization". The Journal of Cell Biology 180 (4): 681–9. 3. Melchior, C., Kreis, S., Janji, B., Kieffer, N. Promoter characterization and genomic organization of the gene encoding integrin-linked kinase 1. Biochim. Biophys. Acta 1575: 117-122, 2002.
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Gene Name
ILK
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Protein Name
Integrin-linked protein kinase
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Gene Full Name
integrin linked kinase
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Synonyms
HEL S 28 | ILK 1 | ILK-1 | ILK1 | ILK 2 | ILK-2 | ILK2 | ILK | Integrin linked Kinase | p59 | p59ILK | Q13418
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Uniprot ID
Q13418
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Entrez GeneID
3611
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
ILK
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Short name
Integrin linked ILK Antibody
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Technique
Antibody, antibodies against human proteins, antibodies for
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Alternative name
Integrin linked integrin-linked kinase (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
integrin-linked kinase, HEL-S-28 and ILK-1 and ILK-2 and P59 and p59ILK, ILK and IDBG-29381 and ENSG00000166333 and 3611, transferase activity, nuclei, Ilk and IDBG-204955 and ENSMUSG00000030890 and 16202, ILK and IDBG-634121 and ENSBTAG00000000696 and 540207
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Gene info
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Identity
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Gene
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Long gene name
integrin linked kinase
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Synonyms gene name
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GenBank acession
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Locus
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Discovery year
1997-05-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ankyrin repeat domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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