Integrin beta 3 Antibody, ALEXA FLUOR 555

• Catalog number
  bs-0342R-A555
• Price
  Please ask
• Size
  100ul

• Long name
  Integrin beta 3 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
• Also known as
  Anti-Integrin beta 3 PAb ALEXA FLUOR 555
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 555
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Integrin beta 3
• Specificity
  This is a highly specific antibody against Integrin beta 3.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  27-77/788
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Integrin beta 3
• Gene ID Number
  3690
• Swiss Prot
  P05106
• Tested applications
  IF(IHC-P), IF(ICC)
• Recommended dilutions
  IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
• Crossreactivity
  Human, Mouse
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  553nm/568nm
• Synonyms
  GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; Integrin beta-3; Platelet membrane glycoprotein IIIa; ITGB3
• Properties
  For facs or microscopy Alexa 1 conjugate. Very high photo stable ALEXA conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 555
• French translation
  anticorps

• Gene target
  Integrin   beta  
• Gene symbol
  ITGB3BP, ITGB3, ITGB2
• Short name
  Anti-Integrin beta 3
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 555
• Alternative name
  Integrin beta 3 Polyclonal Antibody, ALEXA FLUOR 555
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6157
• Gene
  ITGB3BP
• Long gene name
  integrin subunit beta 3 binding protein
• Synonyms gene name
  • integrin beta 3 binding protein (beta3-endonexin)
• Synonyms
  • NRIF3
  • HSU37139
  • TAP20
  • CENPR
• Synonyms name
  • centromere protein R
  • beta3-endonexin
• GenBank acession
  • U37139
• Locus
  1p31.3
• Discovery year
  2000-05-08
• Entrez gene record
  23421
• Pubmed identfication
  • 7593198
  • 10490654
• RefSeq identity
  • NM_014288
• Classification
  • Constitutive centromere associated network
• VEGA ID
  OTTHUMG00000013364

Gene info

• Identity
  HGNC:6156
• Gene
  ITGB3
• Long gene name
  integrin subunit beta 3
• Synonyms gene
  • GP3A
• Synonyms gene name
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
• Synonyms
  • CD61
  • GPIIIa
• Synonyms name
  • platelet glycoprotein IIIa
  • antigen CD61
• Locus
  17q21.32
• Discovery year
  1988-06-09
• Entrez gene record
  3690
• Pubmed identfication
  • 2454952
• RefSeq identity
  • NM_000212
• Classification
  • CD molecules
  • Integrin beta subunits
• VEGA ID
  OTTHUMG00000171956
• Locus Specific Databases
  • LRG_481

Gene info

• Identity
  HGNC:6155
• Gene
  ITGB2
• Long gene name
  integrin subunit beta 2
• Synonyms gene
  • CD18
  • MFI7
• Synonyms gene name
  • integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
• Synonyms
  • LFA-1
  • MAC-1
• Synonyms name
  • complement component 3 receptor 3 and 4 subunit
• GenBank acession
  • AK222505
• Locus
  21q22.3
• Discovery year
  1986-01-01
• Entrez gene record
  3689
• RefSeq identity
  • NM_000211
• Classification
  • Integrin beta subunits
  • Complement system regulators and receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000090257
• Locus Specific Databases
  • ITGB2base: Mutation registry for Leukocyte adhesion deficiency I (LAD-I)
  • LRG_76

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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