Tap1 Antibody

• Catalog number
  bs-2789R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Tap1 Primary Polyclonal Antibody
• Also known as
  Tap1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Tap1
• Specificity
  This is a highly specific antibody against Tap1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  525-575/808
• Subcellular location
  Cytoplasm
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Tap1/ABCB2
• Gene ID number
  6890
• Swiss Prot
  Q03518
• Tested Applications
  WB, FCM, IHC-P, IF(IHC-P), IF(ICC)
• Recommended dilutions
  WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-1 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  APT1; PSF1; ABC17; ABCB2; PSF-1; RING4; TAP1N; D6S114E; TAP1*12N; Antigen peptide transporter 1; ATP-binding cassette sub-family B member 2; Peptide supply factor 1; Peptide transporter PSF1; Peptide transporter TAP1; Peptide transporter involved in antigen processing 1; Really interesting new gene 4 protein; TAP1; Y3
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Tap1  
• Gene symbol
  PSMB8-AS1, TAP1, SEC14L2
• Short name
  Anti-Tap1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Tap1 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), ABC17 and ABCB2 and APT1 and D6S114E and PSF-1 and PSF1 and RING4 and TAP1*0102N and TAP1N, TAP1 and IDBG-81568 and ENSG00000168394 and 6890, ATPase activity, Plasma membranes, Tap1 and IDBG-170616 and ENSMUSG00000037321 and 21354, TAP1 and IDBG-628856 and ENSBTAG00000008953 and 524959

Gene info

• Identity
  HGNC:39758
• Gene
  PSMB8-AS1
• Long gene name
  PSMB8 antisense RNA 1 (head to head)
• Synonyms gene
  • TAPSAR1
• Synonyms gene name
  • TAP1 and PSMB8 antisense RNA 1
• Synonyms
  • XXbac-BPG246D15.8
  • TAP1-AS1
• Locus
  6p21.32
• Discovery year
  2013-07-25
• Entrez gene record
  100507463
• Pubmed identfication
  • 32151711
• RefSeq identity
  • NR_037173
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000140123

Gene info

• Identity
  HGNC:43
• Gene
  TAP1
• Long gene name
  transporter 1, ATP binding cassette subfamily B member
• Synonyms gene
  • ABCB2
• Synonyms gene name
  • transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
• Synonyms
  • PSF1
  • RING4
  • D6S114E
• Locus
  6p21.32
• Discovery year
  1992-06-25
• Entrez gene record
  6890
• Pubmed identfication
  • 1529427
  • 1946428
• RefSeq identity
  • NM_000593
• Classification
  • ATP binding cassette subfamily B
• VEGA ID
  OTTHUMG00000031067
• Locus Specific Databases
  • TAP1base: Mutation registry for TAP1 deficiency
  • IMGT/HLA Database
  • LRG_166

Gene info

• Identity
  HGNC:10699
• Gene
  SEC14L2
• Long gene name
  SEC14 like lipid binding 2
• Synonyms gene
  • C22orf6
• Synonyms gene name
  • SEC14 (S. cerevisiae)-like 2
  • SEC14-like 2 (S. cerevisiae)
  • SEC14-like lipid binding 2
• Synonyms
  • TAP
  • SPF
  • KIAA1186
  • KIAA1658
  • TAP1
• Synonyms name
  • supernatant protein factor
  • tocopherol-associated protein 1
• GenBank acession
  • AL096881
• Locus
  22q12.2
• Discovery year
  1999-10-12
• Entrez gene record
  23541
• Pubmed identfication
  • 10829015
  • 17428729
  • 12757856
• RefSeq identity
  • NM_012429
• Classification
  • SEC14 family
• VEGA ID
  OTTHUMG00000151024

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products