TIMP3 Antibody

• Catalog number
  R30261
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  TIMP3
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 0.5-1ug/ml,ELISA: 0.1-0.5ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the TIMP3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This TIMP3 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P35625
• Purity
  Antigen affinity
• Description
  The tissue inhibitors of metalloproteinases(TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy(SFD).
• Immunogen
  An amino acid sequence from the C-terminus of human TIMP3 (WAPPDKSIINATDP) was used as the immunogen for this TIMP3 antibody.
• Storage
  After reconstitution, the TIMP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TIMP3  
• Gene symbol
  TIMP3
• Short name
  Anti-TIMP3
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to TIMP3
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11822
• Gene
  TIMP3
• Long gene name
  TIMP metallopeptidase inhibitor 3
• Synonyms gene
  • SFD
• Synonyms gene name
  • tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
• Locus
  22q12.3
• Discovery year
  1993-04-12
• Entrez gene record
  7078
• Pubmed identfication
  • 8188246
  • 12652295
• RefSeq identity
  • NM_000362
• Classification
  • Tissue inhibitor of metallopeptidases
• VEGA ID
  OTTHUMG00000030784
• Locus Specific Databases
  • Mutations of the Tissue Inhibitor of Metalloproteases 3 Gene

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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