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IL10 protein Mouse

IL10 protein Mouse is available 4 times from Fitzgerald labs

30R-AI005x | IL10 protein (Mouse) size: 2 ug | 283.73 USD

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30R-AI005 | IL10 protein (Mouse) size: 10 ug | 434.29 USD

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30R-AI005x | IL10 protein Mouse size: 2 µg | 193.4 USD

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30R-AI005 | IL10 protein Mouse size: 10 µg | 378.7 USD

Catalog number 30R-AI005
Supplier fitzgerald
Price378.7 USD
Size 10 µg
Form & Buffer Lyophilized from 10 mM Sodium Phosphate, pH 7.0, sterile filtered through a 0.2 um filter. Reconstitute in water to a concentration of 0.1-1.0mg/ml.
Short name IL10 protein Mouse
Alternative name interleukin 10 protein Mouse
1. Gene info
Identity5962
GeneIL10
Long gene name interleukin 10
GenBank acession
Locus1q32.1
Discovery year 1991-10-31
Entrez gene record3586
Pubmed identfication
RefSeq identity
Classification
  • Interleukins
Havana BLAST/BLATOTTHUMG00000036386
Additional information
PubMedEndogenous IL-10 is not essential in EAT, or for the immune deviation induced by thyroid FasL expression, whereas it is necessary for the immune privilege status of the thyroid conferred by FasL expression on thyrocytes.
Data (including data from studies in knockout mice) suggest that up-regulation of signaling in colonic mucosa via interleukin-10/microRNA-155/SHIP-1 (Src homology 2 domain-containing inositol-5-phosphatase) is involved in development of colitis due to dysbiosis.
In this review IL-10 is a regulatory cytokine with a pleiotropic role in the immune system, operating primarily as a feedback inhibitor of exuberant T cell responses to microbial antigens.
Tim-1 is critical for maintaining self-tolerance by regulating IL-10 production in Bregs
TGF-beta and IL-10 redundantly suppress hepatic inflammation during acute S. mansoni infection while intestinal inflammation is regulated by alternatively activated macrophages.
IL-10 is not required for the induction of low dose oral tolerance but is required for the regulation of INF-gamma which affects severity of experimental autoimmune encephalomyelitis in tolerized mice
upon maturation, dendritic cells are reprogrammed with a distinct cytokine-secreting profile, which may play an important role in regulating T cell functions
the IL10 gene transcription did not associate with enhancement of c-Jun, RelA and FOXP3 gene expression and strictly depended on the JNK and p38 MAPKs activation in stimulated human monocytes.
The proinflammatory cytokine IL-12 was necessary for NK cell induction of IL-10.
Treg-mediated improvement in flow was abolished by employing blocking anti-IL-10 antibodies
Gene ontology - Cellular componentextracellular space
extracellular region
Gene ontology - Molecular functioncytokine activity
interleukin-10 receptor binding
Entrez Geneinterleukin 10
Product images
    #IL10#.jpg#Mouse#.jpg
Residues Region of IL10 protein corresponding to amino acids MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGQKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGVYKA MNEFDIFINC IEAYMMIKMK S.
Grade & Purity Grater than 98% pure
Category Proteins
Tested for Please refer to the datasheet
Product Subtype Recombinant Proteins
Expression System Escherichia coli
Type1 Recombinant
Antibody Subtype Recombinant Proteins
Shipping Info Blue Ice
Shipping conditions Blue Ice
Applications User optimized
Research Area Cytokines & Growth Factors
Type of protein Recombinant
Tag/Conjugate Region of IL10 protein corresponding to amino acids MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGQKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGVYKA MNEFDIFINC IEAYMMIKMK S.
Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Reactivity Mouse
Product Type Proteins
Area of research Cytokines & Growth Factors
Bioactivity PeproTech's Mouse IL-10 is fully biologically active as measured by the dose-dependent co-stimulation (with IL-4) of the proliferation of Mouse MC/9 cells. The ED50 was found to be 5 x 10^5 units/mg.
Gene Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. Recombinant. coli interleukin-1o for cell culture or antibody production.
Test Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin name Mus musculus
Gene targetIL10 protein
Technique Mouse
Host mouse
Species Mouse
Alternative technique murine
Alternative to gene target interleukin 10, CSIF and GVHDS and IL-10 and IL10A and TGIF, IL10 and IDBG-106270 and ENSG00000136634 and 3586, growth factor activity, Extracellular, Il10 and IDBG-190697 and ENSMUSG00000016529 and 16153, IL10 and IDBG-629159 and ENSBTAG00000006685 and 281246
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