IL-6 Recombinant Protein

  • Catalog number
    40-112
  • Price
    Please ask
  • Size
    0.002 mg, 0.01 mg
  • About recombinant protein
    IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R alpha and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
  • Other name of the recombinant
    Il-6, Il-6, Interleukin-6, B-cell hybridoma growth factor, IL-6
  • Recombinant in
    E. coli
  • SEQUENCE
    MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT
  • Activity
    The ED50 was determined by the dose - dependent stimulation of the proliferation of IL - 6 - dependent murine 7TD1 cells is < 0.02 ng/mL, corresponding to a specific activity of > 5 x 107 units/mg.
  • Keep at
    The lyophilized IL-6 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted IL-6 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing IL-6 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
  • Rec PROTEIN GI
    13624311
  • Accession nr
    NP_112445.1
  • Pureity
    Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
  • About
    This product is for research use only.
  • Protein s origin
    Murine
  • Vial
    Lyophilized
  • NCBI ID
    16193
  • Gene name
    interleukin 6
  • Source
    Mus musculus
  • Uniprot
    P08505
  • Pictures of recombinant
  • Rec pdf
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    IL-6   Protein  
  • Gene symbol
    Il6
  • Short name
    IL-6 Recombinant Protein
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Alternative name
    Interleukin-6 Rec. Protein
  • Alternative technique
    rec
Gene info
  • Identity
    HGNC:40301
  • Gene
    IL6-AS1
  • Long gene name
    IL6 antisense RNA 1
  • Locus
    7p15.3
  • Discovery year
    2019-08-14
  • Entrez gene record
    541472
  • RefSeq identity
  • Classification
    • Antisense RNAs
Gene info
Gene info
MeSH Data
  • Name
    Primary Cell Culture
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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