IkBa Antibody

• Catalog number
  R31704
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  IkBa
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the IkBa antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This IkBa antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  4792
• Purity
  Antigen affinity
• Description
  NFKBIA, also called IkBa or MAD-3, is one member of a family of cellular proteins that function to inhibit the NF-kB transcription factor. It inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. It moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. The effect of the nonpathogenic bacteria is specific to the SCF complex substrates beta Catenin and IkBa. This may help to explain the beneficial effects of treatment of inflammatory bowel disease with nonpathogenic probiotic enteric organisms. In addition, IkBa blocks the ability of NFkB transcription factors to bind to DNA, which is required for proper NFkB functioning.
• Immunogen
  Human partial recombinant protein (AA 3-112) was used as the immunogen for this IkBa antibody.
• Storage
  After reconstitution, the IkBa antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  IkBa  
• Gene symbol
  NFKBIA
• Short name
  Anti-IkBa
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to IkBa
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7797
• Gene
  NFKBIA
• Long gene name
  NFKB inhibitor alpha
• Synonyms gene
  • NFKBI
• Synonyms gene name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
• Synonyms
  • IKBA
  • MAD-3
  • IkappaBalpha
• Synonyms name
  • NF-kappa-B inhibitor alpha
• Locus
  14q13.2
• Discovery year
  1992-02-13
• Entrez gene record
  4792
• Pubmed identfication
  • 1829648
• RefSeq identity
  • NM_020529
• Classification
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000140220
• Locus Specific Databases
  • NFKBIAbase: Mutation registry for Autosomal dominant anhidrotic ectodermal dysplasia and T-cell immunodeficiency
  • LRG_89

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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