IDO Pathway inhibitor
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Catalog number2746-50
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PricePlease ask
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Size50 mg
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Alternative_name1-Methyl-D-tryptophan; Indoximod
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DescriptionIDO pathway inhibitor is a methylated tryptophan with anti-immunosuppressive activity. 1-Methyl-D-tryptophan inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function.
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CAS Number110117-83-4
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Structure AvailableY
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Salt FormNo
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Molecular FormulaC₁₂H₁₄N₂O₂
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Molecular Weight218.25
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Cell PermeableYes
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Purity≥95%
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineAn IDO pathway inhibitor
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Storage Condition-20°C
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Shipping ConditionGel Pack
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Shelf Life36 months
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MDL NumberMFCD00274271
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PubChem CID405012
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SMILESCN1C=C(C2=CC=CC=C21)CC(C(=O)O)N
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InChiInChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1
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InChi KeyZADWXFSZEAPBJS-SNVBAGLBSA-N
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolIDO1
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Short nameIDO Pathway inhibitor
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Alternative nameIndoleamine 2,3-dioxygenase 1 Pathway suppressor
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Gene info
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Identity
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Gene
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Long gene nameindoleamine 2,3-dioxygenase 1
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Synonyms gene
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Synonyms gene name
- indoleamine-pyrrole 2,3 dioxygenase
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GenBank acession
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Locus
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Discovery year1993-05-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID