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Stock availabilitIn Stock
In Stock
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CAS number
747-36-4
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Description
Autophagy inhibitor
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Molecular weight
433,95 g/mol
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Primary research fields
Cancer, Autophagy
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Other name
Hydroxychloroquine sulphate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C18H26ClN3O•H2SO4
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Origin
Synthetic
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Purity pourcentage
≥98%
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Soluble in
Soluble in greater than 20 mg/ml H2O.
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Physical appearance
White to off-white powder.
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Acute toxicity, Oral (Category 4), Eye irritation (Category 2A) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H319- Causes serious eye irritation. Precautionary statements: P264- Wash skin thoroughly after handling. P270- Do not eat, drink or smoke when using this product. P280- Wear protective gloves/ eye protection/ face protection. P301 + P312- IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P330- Rinse mouth. P337 + P313- If eye irritation persists: Get medical advice/ attention. P501- Dispose of contents/ container to an approved waste disposal plant.
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PubChem number
12947
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Scientific context
Hydroxychloroquine was first established as an anti-malarial agent, but is now being used in a variety of applications, including the inhibition of autopagy. Hydroxychloroquine is a lysosomotropic agent and therefore inhibits autophagy by obstructing the final step of autophagy, the fusion of autophagosomes with lysosomes, thereby preventing the acidification of the lysosomal compartment. In the context of cancer, autophagy is thought to be adopted by tumor cells to survive in the nutrient-deficient and hypoxic tumor environment. Hydroxychloroquine has therefore been studied extensively within the context of certain cancers.
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Bibliography
1. van Loosdregt J., et al. (2013) J Allergy Clin Immunol. 131(5): 1443-6.e1. 2. Lotze M.T., et al. (2013) Cancer J. 19(4): 341-7. 3. Xie X., et al. (2013) PLoS One. 8(1): e55096.
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Release date
31-Mar-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Hydroxychloroquine (SIH-400), a Autophagy inhibitor. CAS #: 747-36-4. Molecular Formula: C18H26ClN3O · H2SO4. Molecular Weight: 433.95 g/mol. Chemical structure of Hydroxychloroquine, a Autophagy inhibitor (SIH-400). CAS # 747-36-4. Molecular Formula: C18H26ClN3O · H2SO4.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.01
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
