HVEM-Fc protein

Category

Proteins
Antibody Subtype

Recombinant Proteins
Area of research

Cytokines & Growth Factors
Reactivity

Human
Residues

Region of HVEM protein corresponding to amino acids LPSCKEDEYP VGSECCPKCS PGYRVKEACG ELTGTVCEPC PPGTYIAHLN GLSKCLQCQM CDPAMGLRAS RNCSRTENAV CGCSPGHFCI VQDGDHCAAC RAYATSSPGQ RVQKGGTESQ DTLCQNCPPG TFSPNGTLEE CQHQTKRSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK. Conjugated to Fc.
Type of protein

Recombinant
Expression System

Hi-5 cells
Grade Purity

Grater than 98% pure
Form Buffer

Provided as a lyophilized powder.
Storage

Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Shipping conditions

Blue Ice
Tested for

Please refer to the datasheet
Bioactivity

Determined by its ability to neutralize 0.25 ng/ml of hTNFbeta induced cytotoxicity on Mouse L929 cells. The expected ED50 for this effect is 1.3-1.9 ug/ml of HVEM-Fc.
Additional Information

Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.
URL
More info

Identity

HGNC:11912
Gene

TNFRSF14
Long gene name

TNF receptor superfamily member 14
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
- tumor necrosis factor receptor superfamily, member 14
Synonyms
- HVEM
- ATAR
- TR2
- LIGHTR
- HVEA
- CD270
Synonyms name
- herpesvirus entry mediator
GenBank acession
- U70321
Locus

1p36.32
Discovery year

1998-12-04
Entrez gene record

8764
Pubmed identfication
- 8898196
- 9162061
Classification
- Tumor necrosis factor receptor superfamily
- CD molecules
VEGA ID

OTTHUMG00000000792