TNF-R1:Fc, Recombinant, Human (p55, CD120a, TNFRSF 1A, Tumor Necrosis Factor Receptor Superfamily Member 1A, TNF Receptor 1)

• Catalog number
  MBS637648
• Price
  Please ask
• Size
  0.05 mg

• Products_type
  Active Protein
• Products_short_name
  [TNF-R1:Fc]
• Specificity
  Binds human and mouse TNF-alpha.
• Purity
  Highly Purified>95% (SDS-PAGE)
• Form
  Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
• Storage_stability
  Short-term Storage: +4 degree CLong-term Storage: -20 degree CStable for at least 6 months after receipt when stored at -20 degree C.
• Description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants
• Gene
  Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

• Gene target
  TNF-R1   p55   CD120a   TNFRSF   Tumor   Necrosis   Factor   Receptor   Superfamily   Member   TNF   Receptor  
• Gene symbol
  TNFRSF1A, TNF, TNFRSF1B, LTBR, C17orf75, CDCA7L, CNEP1R1, CXCL11, PNPLA7, PCAT6
• Short name
  TNF-R1:Fc, Recombinant, (p55, CD120a, TNFRSF 1A, Tumor Necrosis Factor Receptor Superfamily Member 1A, TNF Receptor 1)
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  Human, HEK 293 cells
• Species
  Human, Humans
• Alternative name
  tumor necrosis factor-R1:fragment c, Rec., H. sapiens (p55, CD120a, TNFRSF 1A, Tumor Necrosis Factor Receptor supergroup Member 1A, tumor necrosis factor Receptor 1)
• Alternative technique
  rec
• Alternative to gene target
  tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943
• Tissue
  tumor

Gene info

• Identity
  HGNC:11916
• Gene
  TNFRSF1A
• Long gene name
  TNF receptor superfamily member 1A
• Synonyms gene
  • TNFR1
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1A
• Synonyms
  • TNF-R
  • TNFAR
  • TNFR60
  • TNF-R-I
  • CD120a
  • TNF-R55
• GenBank acession
  • M75866
• Locus
  12p13.31
• Discovery year
  1991-01-15
• Entrez gene record
  7132
• Pubmed identfication
  • 1655358
  • 2158863
• RefSeq identity
  • NM_001065
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000168267
• Locus Specific Databases
  • INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
  • LRG_193

Gene info

• Identity
  HGNC:11892
• Gene
  TNF
• Long gene name
  tumor necrosis factor
• Synonyms gene
  • TNFA
• Synonyms gene name
  • tumor necrosis factor (TNF superfamily, member 2)
• Synonyms
  • TNFSF2
  • DIF
  • TNF-alpha
• Synonyms name
  • TNF superfamily, member 2
• GenBank acession
  • X02910
• Locus
  6p21.33
• Discovery year
  1986-01-01
• Entrez gene record
  7124
• Pubmed identfication
  • 2413547
  • 6392892
• Classification
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000031194

Gene info

• Identity
  HGNC:11917
• Gene
  TNFRSF1B
• Long gene name
  TNF receptor superfamily member 1B
• Synonyms gene
  • TNFR2
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1B
• Synonyms
  • TNFBR
  • TNFR80
  • TNF-R75
  • TNF-R-II
  • p75
  • CD120b
• GenBank acession
  • M32315
• Locus
  1p36.22
• Discovery year
  1991-01-15
• Entrez gene record
  7133
• Pubmed identfication
  • 2158863
  • 8702885
• RefSeq identity
  • NM_001066
• Classification
  • CD molecules
  • MicroRNA protein coding host genes
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000001829

Gene info

• Identity
  HGNC:6718
• Gene
  LTBR
• Long gene name
  lymphotoxin beta receptor
• Synonyms gene
  • D12S370
• Synonyms
  • TNFCR
  • TNFR-RP
  • TNFR2-RP
  • TNF-R-III
  • TNFRSF3
• Synonyms name
  • TNFR superfamily, member 3
• GenBank acession
  • L04270
• Locus
  12p13.31
• Discovery year
  1996-03-12
• Entrez gene record
  4055
• Pubmed identfication
  • 8171323
  • 8486360
• Classification
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000168356

Gene info

• Identity
  HGNC:30173
• Gene
  C17orf75
• Long gene name
  chromosome 17 open reading frame 75
• Synonyms
  • NJMU-R1
  • SRI2
• Synonyms name
  • sensitization to ricin complex subunit 2
• GenBank acession
  • AB062437
• Locus
  17q11.2
• Discovery year
  2006-01-12
• Entrez gene record
  64149
• Pubmed identfication
  • 23394947
  • 29426865
• RefSeq identity
  • NM_022344
• VEGA ID
  OTTHUMG00000179585

Gene info

• Identity
  HGNC:30777
• Gene
  CDCA7L
• Long gene name
  cell division cycle associated 7 like
• Synonyms gene name
  • cell division cycle associated 7-like
• Synonyms
  • RAM2
  • R1
  • JPO2
• Locus
  7p15.3
• Discovery year
  2005-05-13
• Entrez gene record
  55536
• Pubmed identfication
  • 16829576
• RefSeq identity
  • NM_018719
• VEGA ID
  OTTHUMG00000128429

Gene info

• Identity
  HGNC:26759
• Gene
  CNEP1R1
• Long gene name
  CTD nuclear envelope phosphatase 1 regulatory subunit 1
• Synonyms gene
  • C16orf69
  • TMEM188
• Synonyms gene name
  • chromosome 16 open reading frame 69
  • transmembrane protein 188
• Synonyms
  • FLJ38101
  • NEP1-R1
• Synonyms name
  • nuclear envelope phosphatase 1-regulatory subunit 1
• GenBank acession
  • AK095420
• Locus
  16q12.1
• Discovery year
  2006-04-07
• Entrez gene record
  255919
• Pubmed identfication
  • 22134922
• RefSeq identity
  • NM_153261
• VEGA ID
  OTTHUMG00000173447

Gene info

• Identity
  HGNC:10638
• Gene
  CXCL11
• Long gene name
  C-X-C motif chemokine ligand 11
• Synonyms gene
  • SCYB9B
  • SCYB11
• Synonyms gene name
  • small inducible cytokine subfamily B (Cys-X-Cys), member 11
  • chemokine (C-X-C motif) ligand 11
• Synonyms
  • H174
  • b-R1
  • I-TAC
  • IP-9
• GenBank acession
  • U66096
• Locus
  4q21.1
• Discovery year
  1998-06-23
• Entrez gene record
  6373
• Pubmed identfication
  • 9730616
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000130101

Gene info

• Identity
  HGNC:24768
• Gene
  PNPLA7
• Long gene name
  patatin like phospholipase domain containing 7
• Synonyms gene
  • C9orf111
• Synonyms gene name
  • chromosome 9 open reading frame 111
  • patatin-like phospholipase domain containing 7
• Synonyms
  • FLJ43070
  • FLJ31318
  • FLJ44279
  • RP11-48C7.2
  • NTEL1
  • NTE-R1
• GenBank acession
  • AK126267
• Locus
  9q34.3
• Discovery year
  2004-03-25
• Entrez gene record
  375775
• Pubmed identfication
  • 16799181
  • 12640454
  • 19029121
• RefSeq identity
  • NM_152286
• Classification
  • Patatin like phospholipase domain containing
• VEGA ID
  OTTHUMG00000020990

Gene info

• Identity
  HGNC:43714
• Gene
  PCAT6
• Long gene name
  prostate cancer associated transcript 6
• Synonyms gene
  • KDM5B-AS1
• Synonyms gene name
  • KDM5B antisense RNA 1 (head to head)
  • prostate cancer associated transcript 6 (non-protein coding)
• Synonyms
  • ncRNA-a2
  • PCAN-R1
  • KDM5BAS1
  • onco-lncRNA-96
• Synonyms name
  • prostate cancer-associated noncoding RNA 1
• GenBank acession
  • BI962506
  • AI806248
• Locus
  1q32.1
• Discovery year
  2012-02-02
• Entrez gene record
  100506696
• Pubmed identfication
  • 20887892
  • 23728290
• RefSeq identity
  • NR_046325
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000041399

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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