Human Tau 441 Recombinant protein

2x Human Tau 441 Recombinant protein found in Biovision

  • Scientific context
    Tau is a microtubule-associated protein involved in Alzheimer’s and Parkinson’s disease. It promotes microtubule assembly and stability, and might participate in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
  • Specific targetted sequence
    MGSSHHHHHHSSGLVPRGSH - MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
  • Molecular weight (in Da)
    48 kDa
  • Protein target
    MAPT
  • Other name
    MAPTL, MTBT1, TAU, Neurofibrillary tangle protein, Paired helical filament-tau
  • Gene origin
    Human
  • Gene number
    4137 (MAPT)
  • Protein number
    P10636
  • Source
    E.coli
  • Application
    SDS-PAGE (Purity > 90% )
  • Endotoxins
    N/A
  • Specific activity
    N/A
  • Bioactivity
    N/A
  • Example results
    N/A
  • Unit Definition
    N/A
  • Handling and storage
    Centrifuge the vial prior to opening. Store for 12 months at -20°C
  • Delivery
    Shipped under gel pack
  • Package form
    This product is supplied as lyophilized form in PBS
  • Reconstitute
    Reconstitute to 4 mg/mL in sterile water.
  • Precautions
    Manufactured in USA. For Research Use Only! Not to be used in humans
  • Released
    Manifactured since May 2017. Available to order. Please contact us for larger or bulk quantity
  • Gene target
  • Short name
    Tau-441 Recombinant protein
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Human, Humans
  • Alternative name
    H. sapiens Taurine-441 recombinant protein
  • Alternative technique
    rec

P1192-250 | Human Tau-441 Recombinant protein250 μg 1255.94 USD

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P1192-50 | Human Tau-441 Recombinant protein50 μg 362.17 USD

  • Catalog number
    P1192-50
  • Supplier
  • Price
    362.17 USD
  • Size
    50 μg
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
MeSH Data
  • Name
  • Concept
    Scope note:The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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