Human Stathmin 1 / STMN1 Protein

  • Catalog number
    7881-100
  • Price
    Please ask
  • Size
    100 ug
  • Synonyms
    STMN1, Stathmin, C1orf215, LAP18, OP18
  • Alternative_names
    STMN1, Stathmin, C1orf215, LAP18, OP18
  • Description
    An important regulatory protein of microtubule dynamics.
  • Recombinant
    Yes
  • Source
    E. coli
  • Purity by SDS PAGE
    >92%
  • Assay
    SDS-PAGE
  • Molecular Weight
    18.1 kDa
  • Storage Temp
    +4°C
  • Shipping
    Gel Pack
  • Shelf Life
    12 months
  • Appearance
    Dry powder
  • Physical form description
    Lyophilized powder
  • Reconstitution Instructions
    Reconstitute in sterile PBS, pH7.4 to a stock solution of 400 µg/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% (W/V) HSA or BSA) is recommended for further dilution and long term storage.
  • Background Information
    Stathmin (STMN1), a member of the stathmin family, is also known as Leukemia-associated phosphoprotein p18, Oncoprotein 18 (Op18), Phosphoprotein p19 (pp19), Protein Pr22 and pp17, which contains one SLD (stathmin-like) domain. The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized. Stathmin (STMN1) interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization, there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.
  • Amino acid sequence
    Ala 2 - Asp 149
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Gene target
  • Gene symbol
    STMN1
  • Short name
    Stathmin 1 / STMN1 Protein
  • Species
    Human, Humans
  • Alternative name
    H. sapiens Stathmin 1 / STMN1 Protein
Gene info
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