Human Recombinant Ubiquitin K29R
Human Recombinant Ubiquitin K29R is available 2 times from Biovision labs
6406-500 | Human Recombinant Ubiquitin-K29Rsize: 500 μg | 183.09 USD
6406-1000 | Human Recombinant Ubiquitin-K29Rsize: 1 mg | 265.37 USD
- BackgroundUbiquitin is a small polypeptide that can be conjugated via its C-terminus to amine groups of lysine residue on target proteins. This conjunction is referred to as monoubiquitylation. Additional ubiquitin moieties can be subsequently conjugated to this initial ubiquitin, utilizing any one of the seven lysine residues on the surface of ubiquitin. The formation of these ubiquitin chains is referred to as polyubiquitylation. This tag-free recombinant form of human ubiquitin is engineered to have a single substitution of arginine for lysine at position 29. Covalent attachment of ubiquitin to other proteins serves various functions, but its major role is to target cellular proteins for destruction. Cellular components that activate, transfer, remove, or simply recognize ubiquitin number in the hundreds, perhaps even in the thousands. In light of this complexity the ubiquitin pathway is ideal for a systems biology approach. Ubiquitin plays a very important role in regulated non-lysosomal ATP dependent protein degradation. The Ub-proteasome proteolytic pathway, which is a complex process, is implicated to be of great importance for regulating numerous cellular processes.
- Concentration4 mg/ml
- Molecular weight8.592 kDa
- SynonymHuman Recombinant Ubiquitin-K29R
- NCBI gene number6233
- NCBI geneRPS27A
- Gene sourceHuman
- NCBI numberP62979
- SourceE. Coli
- Tested applicationsRP-HPLC, N/A
- Level of endotoxinN/A
- Tested activityN/A
- Biological activityN/A
- Binding abilityN/A
- Storage condition-80°C
- Shipping undergel pack
- Physical appearanceLiquid
- Physical properties4 mg/ml in 20 mM Tris, pH 7.5, 0.15 M NaCl and 10% glycerol.
- How to reconstituteN/A
- Aa sequenceN/A
- Before useCentrifuge the vial prior to opening.
- NotesFor Research Use Only! Not to be used in humans
- PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
- Additional sourceRecombinants or rec. proteins
- Gene target
- Short nameRecombinant Ubiquitin-K29R
- Alternative nameH. sapiens recombinant Ubiquitin-K29R
- Alternative techniquerec
Supplier:Brady Benelux NL