Human Recombinant TNF-beta/LTA

Human Recombinant TNF-beta/LTA is available 1 time from Biovision labs

  • Background
    TNF-beta, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. It is highly inducible, secreted, and exists as homotrimeric molecule. It forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. It is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.
  • Concentration
    0.5 mg/ml
  • Molecular weight
    20.9 kDa (192 aa, 35-205 aa + His-Tag)
  • Synonym
    Human Recombinant TNF-beta/LTA
  • Other name
    Lymphotoxin alpha, LT, TNFB, TNFSF1.
  • NCBI gene number
    4049
  • NCBI gene
    LTA
  • Gene source
    Human
  • NCBI number
    P01374
  • Recombinant
    Yes
  • Source
    E. Coli
  • Purification
    ≥90%
  • Tested applications
    SDS-PAGE, N/A
  • Level of endotoxin
    N/A
  • Tested activity
    N/A
  • Biological activity
    Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is
  • Binding ability
    N/A
  • Unit
    N/A
  • Storage condition
    -80°C
  • Shipping under
    gel pack
  • Physical appearance
    Liquid
  • Physical properties
    0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol.
  • How to reconstitute
    N/A
  • Aa sequence
    MGSSHHHHHH SSGLVPRGSH MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQK MVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL
  • Before use
    Centrifuge the vial prior to opening.
  • Notes
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene
    Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.
  • Gene target
  • Short name
    Recombinant TNF-beta/LTA
  • Technique
    Recombinant
  • Species
    Human
  • Alternative name
    H. sapiens recombinant tumor necrosis factor-b/lymphotoxin alpha (tumor necrosis factor superfamily, member 1)
  • Alternative technique
    rec
  • Alternative to gene target
    tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943, lymphotoxin alpha (TNF superfamily, member 1), LT and TNFB and TNFSF1, LTA and IDBG-302490 and ENSG00000226979 and 4049, protein binding, Extracellular, Lta and IDBG-177399 and ENSMUSG00000024402 and 16992, LTA and IDBG-634171 and ENSBTAG00000000016 and 280845

6376-50 | Human Recombinant TNF-beta/LTAsize: 50 μg | 554.56 USD

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