Human Recombinant GRP78 Bip Protein

Human Recombinant GRP78 Bip Protein is available 6 times from Stressmark proteins labs

SPR-119A | Human Recombinant GRP78 (Bip) Proteinsize: 50 µg | 247.4 USD

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SPR-107C | Human Recombinant GRP78 (Bip) Proteinsize: 2x100 µg | 630.18 USD

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SPR-119B | Human Recombinant GRP78 (Bip) Proteinsize: 100 µg | 406.12 USD

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SPR-107B | Human Recombinant GRP78 (Bip) Proteinsize: 100 µg | 367.61 USD

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SPR-107A | Human Recombinant GRP78 (Bip) Proteinsize: 50 µg | 222.9 USD

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SPR-119C | Human Recombinant GRP78 (Bip) Proteinsize: 2x100 µg | 667.52 USD

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  • Stock availability
    In Stock
  • Scientific context
    GRP78 is a ubiquitously expressed, 78-kDa glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1). GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis (2). Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival (3). In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia (Barnes), to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress (4), and its protein levels are reduced in the brains of Alzheimer’s patients (5). Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs (6, 7).
  • Protein target
    GRP78 (Bip)
  • Protein reactivity
    Human
  • Other name
    BIP Protein, Grp78 Protein, HSPA5 Protein, MIF2 Protein, immunoglobulin heavy chain binding Protein
  • Primary research area
    Cancer, Heat Shock, Cell Signaling, Trafficking, Chaperones, Organelle Markers
  • Category
    Protein
  • Brand name
    none
  • Origin
    Recombinant
  • NCBI number
    NM_005347
  • Gene number
    3309
  • Protein number
    P11021
  • Verified applications
    WB, SDS-PAGE, ATPase Activity Assay, Functional Assay, ELISA
  • Protein expression model
    E. coli
  • Peptide sequence
    MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
  • Protein purification
    Affinity Purified
  • Purity pourcentage
    >90% High purity
  • Protein concentration
    Lot/batch specific. See included datasheet.
  • Protein specificity
    ~78 kDa
  • Storage recommendations
    -20°C
  • Shipping recommendations
    Blue Ice or 4°C
  • Supplementary useful information
    Please see included datasheet or contact us
  • Protein cell localization
    Endoplasmic Reticulum Lumen, Melanosome
  • Bibliography
    1. Cho S., et al (2007) Mol Cell Biol. 27(1): 368-83. 2. Yang Y., et al. (1998) J Biol Chem. 273: 25552-25555. 3. Luo S., et al (2006) 26(15): 5688-97. 4. Yu Z., et al. (1999) Exp Neurol. 15: 302-314. 5. Koomagi R., et al. (1999) Anticancer Res. 19: 4333-4336. 6. Laquerre S., et al. (1998) J. Virology. 72: 4940-4949. 7. Dong D., et al. (2005) Cancer Res. 65(13): 5785-91.
  • Warnings
    Non-hazardous materials
  • Protein origin
    Canada
  • Total weight (kg)
    1.4
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Short name
    Recombinant GRP78 (Bip) Protein
  • Technique
    Recombinant
  • Species
    Human
  • Alternative name
    H. sapiens recombinant GRP78 (Bip) Protein
  • Alternative technique
    rec
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