Human Recombinant FKBP3
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Catalog number6342-100
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PricePlease ask
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Size100 ug
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SynonymsHuman Recombinant FKBP3
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Alternative_namesFK506 binding protein 3, FKBP25, PPIase FKBP3, Rotamase
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DescriptionAn immunophilin family protein functioning as a protein folding chaperone
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RecombinantYes
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SourceE. Coli
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Purity by SDS PAGE≥90%
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AssaySDS-PAGE
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Biological activitySpecific activity is > 490 nmoles/min/mg.
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Unit DefinitionSpecific activity is > 490 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1 µmole of suc-AAFP-pNA per minute at 25°C in Tris HCl pH 8.0 using chymotrypsin.
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Molecular Weight25.1 kDa
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Storage Temp-20°C
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Shippinggel pack
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Shelf Life12 months
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Concentration1 mg/ml
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AppearanceLiquid
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Physical form description1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.
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Background InformationFKBP3 is part of a family of immunosuppressant receptors which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 accelerates the folding of proteins. FKBP3 is part of the immunophilin protein family, which participates in immunoregulation and fundamental cellular processes concerning protein folding and trafficking. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a greater affinity for rapamycin than for FK506 and therefore is a significant protein for immunosuppression by rapamycin.
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Amino acid sequenceMAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDID
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolFKBP3
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Short nameRecombinant FKBP3
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHuman, Humans
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Alternative nameH. sapiens Rec. FK506 binding protein 3, 25kDa
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Alternative techniquerec
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Alternative to gene targetFK506 binding protein 3, 25kDa, FKBP-25 and FKBP-3 and FKBP25 and PPIase, FKBP3 and IDBG-5577 and ENSG00000100442 and 2287, poly(A) RNA binding, nuclei, Fkbp3 and IDBG-143170 and ENSMUSG00000020949 and 30795, FKBP3 and IDBG-633002 and ENSBTAG00000002610 and 515069
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Gene info
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Identity
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Gene
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Long gene nameFKBP prolyl isomerase 3
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Synonyms gene name
- FK506-binding protein 3 (25kD)
- FK506 binding protein 3, 25kDa
- FK506 binding protein 3
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-09-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- FKBP prolyl isomerases
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data