Human Recombinant AKR1C3

• Catalog number
  6337-100
• Price
  Please ask
• Size
  100 ug

• Synonyms
  Human Recombinant AKR1C3
• Alternative_names
  Aldo-keto reductase family 1, member C 3, DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5.
• Description
  Involved in in the detoxification of aldehydes and ketones
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Endotoxin Level
  < 1.0 EU per 1 ug of protein (determined by LAL method).
• Biological activity
  The specific activity of AKR1C3 with 5 mM 1-Indanol is approximately 0.3 U/mg.
• Unit Definition
  One unit is the amount of enzyme that reduces 1.0 µmole of NADP+ to NADPH per min. at pH 7.4 at 37°C.
• Molecular Weight
  39 kDa
• Storage Temp
  -20°C
• Shipping
  gel pack
• Shelf Life
  12 months
• Concentration
  1 mg/ml
• Appearance
  Liquid
• Physical form description
  1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
• Background Information
  Aldo-keto reductase family 1 member C3 in humans is encoded by the AKR1C3 gene. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha, 11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation.
• Amino acid sequence
  MGSSHHHHHH SSGLVPRGSH MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD RNLHYFNSDS FASHPNYPYS DEY
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  AKR1C3  
• Gene symbol
  AKR1C3
• Short name
  Recombinant AKR1C3
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  H. sapiens Rec. aldo-keto reductase family 1, member complement component 3 (3-a hydroxysteroid dehydrogenase, classification II)
• Alternative technique
  rec
• Alternative to gene target
  aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), DD3 and DDX and HA1753 and HAKRB and HAKRe and hluPGFS and HSD17B5 and PGFS, AKR1C3 and IDBG-47964 and ENSG00000196139 and 8644, oxidoreductase activity, nuclei

Gene info

• Identity
  HGNC:386
• Gene
  AKR1C3
• Long gene name
  aldo-keto reductase family 1 member C3
• Synonyms gene
  • HSD17B5
• Synonyms gene name
  • hydroxysteroid (17-beta) dehydrogenase 5
  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
• Synonyms
  • KIAA0119
  • DDX
  • HAKRB
  • PGFS
• Synonyms name
  • dihydrodiol dehydrogenase X
  • prostaglandin F synthase
  • 3-alpha hydroxysteroid dehydrogenase, type II
• GenBank acession
  • L43839
• Locus
  10p15.1
• Discovery year
  1998-09-29
• Entrez gene record
  8644
• Pubmed identfication
  • 7650035
  • 9792917
• RefSeq identity
  • NM_003739
• Classification
  • Aldo-keto reductases
• VEGA ID
  OTTHUMG00000017585

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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