Human NLRP3 (Nod Like Receptor Pyrins-3)

Products_type

ELISA Kit
Products_short_name

[NLRP3 (Nod Like Receptor Pyrins-3)]
Products_gene_name

[NLRP3]
Reactivity

Human
Specificity

This assay has high sensitivity and excellent specificity for detection of NLRP3. No significant cross-reactivity or interference between NLRP3 and analogues was observed.
Storage_stability

4 degree C for 6 months
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Gene target

NLRP3 Nod Like Receptor Pyrins-3
Gene symbol

NLRP3
Short name

NLRP3 (Nod Like Receptor Pyrins-3)
Species

Human, Humans
Alternative name

H. sapiens NLR family, pyrin domain containing 3 (Nod Like Receptor Pyrins-3)
Alternative to gene target

NLR family, pyrin domain containing 3, NLRP3 and IDBG-107914 and ENSG00000162711 and 114548, peptidoglycan binding, Cytoplasm, Nlrp3 and IDBG-178924 and ENSMUSG00000032691 and 216799, NLRP3 and IDBG-645402 and ENSBTAG00000001273 and 538639

Identity

HGNC:16400
Gene

NLRP3
Long gene name

NLR family pyrin domain containing 3
Synonyms gene
- C1orf7
- CIAS1
- DFNA34
Synonyms gene name
- cold autoinflammatory syndrome 1
- deafness, autosomal dominant 34
Synonyms
- AGTAVPRL
- AII
- AVP
- FCAS
- FCU
- NALP3
- PYPAF1
- MWS
- CLR1.1
Synonyms name
- Cryopyrin
- nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
GenBank acession
- AF054176
Locus

1q44
Discovery year

2001-08-28
Entrez gene record

114548
Pubmed identfication
- 10741953
RefSeq identity
- NM_004895
Classification
- Pyrin domain containing
- NLR family
VEGA ID

OTTHUMG00000040647
Locus Specific Databases
- INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
- LRG_197