human Choline Kinase alpha 1
human Choline Kinase alpha 1 is available 5 times from Immunodiagnostic new labs
- Gene target
- Short nameCholine Kinase alpha-1
- Alternative nameH. sapiens Choline phosphorylation catalyst a-1
AY1010.1/2 | human Choline Kinase alpha-1size: 100ug | 301.33 USD
AY1009.1/2 | human Choline Kinase alpha-1size: 100ug | 301.33 USD
AY1011.1/2 | human Choline Kinase alpha-1size: 100ug | 301.33 USD
- Catalog numberAY1011.1/2
- Price301.33 USD
- DescriptionThe Choline Kinase alpha-1 is a α- or alpha protein sometimes glycoprotein present in blood.
- PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
- PubMedupregulation of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal cancersA combination of initial velocity and product inhibition studies, together with the kinetic and structural characterisation of a novel ChoKalpha inhibitor is used to support a mechanism of action for human ChoKalpha.Our data suggest that choline kinase and its product phosphocholine are required for the normal growth and mineralization of MG-63 cells.there is a role for the ChoKalpha protein in promoting cancer cell survival that is independent of its catalytic activity.Identify choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma.Downregulation of choline kinase-alpha enhances autophagy in tamoxifen-resistant breast cancer cells.These data also support the approach of antitumor strategies that destabilize Chk-alpha protein or downregulate PtdCho in breast cancer treatment.We found levels of CHKA to be increased in human HCCs compared to nontumor tissues, and increased expression to be associated with tumor aggressiveness. Overexpression of CHKA in HCC cell lines increased their invasiveness, resistance to EGFR inhibitors, and ability to form metastatic tumors in mice by promoting interaction of EGFR with mechanistic target of rapamycin complex 2.
- Gene ontology - Biological process
- Gene ontology - Cellular component
- Gene ontology - Molecular function
- Entrez Gene
AY1013.1/2 | human Choline Kinase alpha-1size: 100ug | 301.33 USD
AY1012.1/2 | human Choline Kinase alpha-1size: 100ug | 301.33 USD