Human CellExp™ Lipocalin-2 / LCN2, rat recombinant
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Catalog number7569-50
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PricePlease ask
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Size50 ug
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SynonymsNGAL, LCN2, Lipocalin-2, 24p3, MSFI, Siderocalin; Oncogene 24p3; Neutrophil Gelatinase-associated Lipocalin; NGAL.
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Alternative_namesNGAL, LCN2, Lipocalin-2, 24p3, MSFI, Siderocalin; Oncogene 24p3; Neutrophil Gelatinase-associated Lipocalin; NGAL.
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DescriptionFunctions as a growth factor and is upregulated during inflammation
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RecombinantYes
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SourceHEK293 cells
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Purity by SDS PAGE≥90%
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AssaySDS-PAGE
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Molecular Weight~25.0 kDa (monomer). Rat lipocalin-2 (aa 1-198) is fused at the C-terminus to a FLAG®-tag.
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Storage Temp-20°C
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ShippingGel Pack
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Shelf Life6 months
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AppearanceLiquid
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Physical form description0.2 um-filtered solution in PBS
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Background InformationLipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), MSFI, The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF alpha) in humans. There are indications that some forms of acne could be caused due to the gene not being transcribed, and that Isotretinoin corrects this. NFAT3 (NFATc4) NFAT by blocking the expression of LCN2 inhibits breast carcinoma cell motility. Recent studies have revealed that NGAL plays an important role in the physiopathology of chronic myeloid leukaemia (CML) mediated by BCR-ABL.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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AboutRats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Latin nameRattus norvegicus
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolLCN2
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Short nameCellExp™ Lipocalin-2 / LCN2, recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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HostRat
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SpeciesHumans, Rats
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Alternative nameH. sapiens CellExp™ Lipocalin-2 / lipocalin 2, rat Rec.
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Alternative techniquerec
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Alternative to gene targetlipocalin 2, 24p3 and MSFI and NGAL, LCN2 and IDBG-87415 and ENSG00000148346 and 3934, protein homodimerization activity, Extracellular, Lcn2 and IDBG-160059 and ENSMUSG00000026822 and 16819, BT.61865 and IDBG-639105 and ENSBTAG00000014149 and 526639
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Gene info
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Identity
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Gene
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Long gene namelipocalin 2
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Synonyms gene name
- lipocalin 2 (oncogene 24p3)
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Synonyms
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Synonyms name
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Locus
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Discovery year1994-04-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Lipocalins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data