Human CellExp ErbB3 HER3 human recombinant

Human CellExp ErbB3 HER3 human recombinant is available 2 times from Biovision labs

  • Target
    ErbB3
  • Background
    ErbB3, also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
  • Concentration
    N/A
  • Molecular weight
    This protein is fused with a C-terminal 6×his tag and has a calculated MW of 71.5 kDa after removal of signal peptide. The predicted N-terminal is Ser 20. Protein migrates as 100-110 kDa in reduced SDS-PAGE resulting from glycosylation.
  • Synonym
    ERBB3, ErbB-3, HER3, HER-3, LCCS2, MDA-BF-1, MGC88033, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, Receptor tyrosine-protein kinase erbB-3
  • Other name
    ERBB3, ErbB-3, HER3, HER-3, LCCS2, MDA-BF-1, MGC88033, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, Receptor tyrosine-protein kinase erbB-3
  • NCBI gene number
    2065
  • NCBI gene
    ErbB3
  • Gene source
    Human
  • NCBI number
    P21860
  • Recombinant
    Yes
  • Source
    HEK293 cells
  • Purification
    ≥95%
  • Tested applications
    SDS-PAGE, N/A
  • Tested activity
    N/A
  • Biological activity
    Measured by its ability to inhibit the biological activity of Neuregulin1-β1 on MCF-7 human breast cancer cells, in the presence of 10 ng/ml recombinant Human NRG1-β1/HRG1-β1 Extracellular Domain. The ED50 for this effect is typically 0.5-3.0 μg/ml
  • Reesults
    Measured by its ability to inhibit the biological activity of Neuregulin1-β1 on MCF-7 human breast cancer cells, in the presence of 10 ng/ml recombinant Human NRG1-β1/HRG1-β1 Extracellular Domain. The ED50 for this effect is typically 0.5-3.0 μg/ml
  • Binding ability
    N/A
  • Unit
    N/A
  • Storage condition
    -20°C
  • Shipping under
    Gel Pack
  • Physical appearance
    Lyophilized
  • Physical properties
    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
  • How to reconstitute
    Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
  • Aa sequence
    N/A
  • Before use
    Centrifuge the vial prior to opening.
  • Notes
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Short name
    CellExp™ ErbB3/HER3, recombinant
  • Technique
    Recombinant
  • Species
    Humans
  • Alternative name
    H. sapiens CellExp™ v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)/HER3, H. sapiens recombinant
  • Alternative technique
    rec
  • Alternative to gene target
    v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), c-erbB-3 and c-erbB3 and ErbB-3 and erbB3-S and HER3 and LCCS2 and MDA-BF-1 and p180-ErbB3 and p45-sErbB3 and p85-sErbB3, ERBB3 and IDBG-39824 and ENSG00000065361 and 2065, this GO :0003197 and endocardial cushion development and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0004716 and receptor signaling protein tyrosine kinase activity and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007162 and negative regulation of cell adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007422 and peripheral nervous system development and biological process this GO :0007507 and heart development and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009968 and negative regulation of signal transduction and biological process this GO :0014037 and Schwann cell differentiation and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016323 and basolateral plasma membrane and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0016328 and lateral plasma membrane and cellular component this GO :0016772 and transferase activity, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019838 and growth factor binding and molecular function this GO :0021545 and cranial nerve development and biological process this GO :0030296 and protein tyrosine kinase activator activity and molecular function this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042060 and wound healing and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043235 and receptor complex and cellular component this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0051048 and negative regulation of secretion and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0061098 and positive regulation of protein tyrosine kinase activity and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process, transferase activity, this GO :0004672: protein kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004714: transmembrane receptor protein tyrosine kinase activity and also this GO :0004716: receptor signaling protein tyrosine kinase activity and also this GO :0004888: transmembrane signaling receptor activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, transferring phosphorus-containing groups and also this GO :0019838: growth factor binding and also this GO :0030296: protein tyrosine kinase activator activity and also this GO :0042803: protein homodimerization activity and also this GO :0046982: protein heterodimerization activity, this GO :0004672: protein kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004714: transmembrane receptor protein tyrosine kinase activity, this GO :0004716: receptor signaling protein tyrosine kinase activity, this GO :0004888: transmembrane signaling receptor activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, transferring phosphorus-containing groups, this GO :0019838: growth factor binding, this GO :0030296: protein tyrosine kinase activator activity, this GO :0042803: protein homodimerization activity, this GO :0046982: protein heterodimerization activity, Extracellular, Erbb3 and IDBG-197943 and ENSMUSG00000018166 and 13867, ERBB3 and IDBG-636302 and ENSBTAG00000010444 and 785655

7400-10 | Human CellExp™ ErbB3/HER3, human recombinantsize: 10 μg | 302.8 USD

  • Catalog number
    7400-10
  • Supplier
  • Price
    302.8 USD
  • Size
    10 μg
1. Gene info
MeSH Data
  • Name
  • Concept
    Scope note:The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
Additional information
Product images

7400-50 | Human CellExp™ ErbB3/HER3, human recombinantsize: 50 μg | 857.94 USD

Ajax processing
Simillar products
Supplier:trca
Price:141.55USD
Supplier:ABM lentivectors
Price:396.97USD
Supplier:trca
Price:311.42USD
Supplier:ABM CrispR
Price:7 165.07USD
Supplier:trca
Price:195.71USD
Supplier:trca
Price:329.88USD
Supplier:acr
Price:401.27USD
Supplier:SFC
Price:0.00USD
Supplier:Molekula
Price:83.70USD
Supplier:ABM microrna
Price:311.42USD
Supplier:aviva
Price:385.27USD
Supplier:MBS Recombinant
Price:1 693.72USD
Supplier:genways
Price:862.86USD
Supplier:ABM microrna
Price:347.11USD
Filters
+32-(0)1-658-90-45 lieven@gentaur.com
Human CellExp ErbB3 HER3 human recombinant - Gentaur.com
Contact
Chat with gentaur.com employee