Human CellExp™ M-CSF R / CSF1R / CD115, Rabbit Recombinant
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Catalog numberP1490-50
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PricePlease ask
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Size50 µg
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SynonymsCSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR
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Alternative_namesCSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR
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DescriptionPlays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells.
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RecombinantTrue
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SourceHEK293 cells
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Purity by SDS PAGE>90%
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Endotoxin LevelLess than 1.0 EU per ug by the LAL method.
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Molecular WeightThis protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.2 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Storage Temp-20ºC
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ShippingGel Pack
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Shelf Life12 months
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AppearanceLyophilized powder
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Physical form descriptionLyophilized
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Reconstitution InstructionsReconstitute in sterile deionized water to a concentration of 50 ug/ml.
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Background InformationColony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
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Amino acid sequenceAA Val 20 - Ser 503
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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AboutRabbits are used for polyclonal antibody production by Biovision. Rabbit antibodies are very stable and can be stored for several days at room temperature. Biovision adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolCSF1, CSF1R, CPT1B, CSF2, IRAK3, PGAM2, CYP20A1, USP16, CYB5B, H3C14
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Short nameCellExp™ M-CSF R / CSF1R / CD115, Rabbit Recombinant
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TechniqueRecombinant, Rabbit, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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HostRabbit, Rabbits
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SpeciesHumans
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Alternative nameH. sapiens CellExp™ M-CSF R / colony stimulating factor 1 receptor / CD115, production species: rabbit Rec.
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Alternative techniquerec, rabbit-anti
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Alternative to gene targetcolony stimulating factor 1 receptor, C-FMS and CD115 and CSF-1R and CSFR and FIM2 and FMS and HDLS and M-CSF-R, CSF1R and IDBG-53268 and ENSG00000182578 and 1436, transferase activity, Cell surfaces, Csf1r and IDBG-150998 and ENSMUSG00000024621 and 12978, CSF1R and IDBG-646265 and ENSBTAG00000012771 and 509418
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Gene info
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Identity
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Gene
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Long gene namecolony stimulating factor 1
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Synonyms gene name
- colony stimulating factor 1 (macrophage)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecolony stimulating factor 1 receptor
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Synonyms gene
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Synonyms gene name
- McDonough feline sarcoma viral (v-fms) oncogene homolog
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Immunoglobulin like domain containing
- Receptor tyrosine kinases
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecarnitine palmitoyltransferase 1B
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Synonyms gene name
- carnitine palmitoyltransferase 1B (muscle)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1996-08-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecolony stimulating factor 2
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Synonyms gene name
- colony stimulating factor 2 (granulocyte-macrophage)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 1 receptor associated kinase 3
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Synonyms gene name
- interleukin-1 receptor-associated kinase 3
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-07-17
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Entrez gene record
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Pubmed identfication
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Classification
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namephosphoglycerate mutase 2
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Synonyms gene name
- phosphoglycerate mutase 2 (muscle)
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Synonyms
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Locus
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Discovery year1989-06-30
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Entrez gene record
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Classification
- Phosphoglycerate mutases
- Bisphosphoglycerate phosphatases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecytochrome P450 family 20 subfamily A member 1
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Synonyms gene name
- cytochrome P450, family 20, subfamily A, polypeptide 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-03-20
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Entrez gene record
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RefSeq identity
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Classification
- Cytochrome P450 family 20
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameubiquitin specific peptidase 16
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Synonyms gene name
- ubiquitin specific protease 16
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-07-09
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Pubmed identfication
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Classification
- Ubiquitin specific peptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecytochrome b5 type B
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Synonyms gene name
- cytochrome b5 type B (outer mitochondrial membrane)
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Synonyms
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Locus
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Discovery year2006-01-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameH3 clustered histone 14
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Synonyms gene
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Synonyms gene name
- H3 histone family, member M
- histone 2, H3c
- histone cluster 2, H3c
- histone cluster 2 H3 family member c
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-02-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- H3 histones
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data