Human CellExp™ M-CSF R / CSF1R / CD115, Rabbit Recombinant

  • Catalog number
    P1490-50
  • Price
    Please ask
  • Size
    50 µg
  • Synonyms
    CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR
  • Alternative_names
    CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR
  • Description
    Plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells.
  • Recombinant
    True
  • Source
    HEK293 cells
  • Purity by SDS PAGE
    >90%
  • Endotoxin Level
    Less than 1.0 EU per ug by the LAL method.
  • Molecular Weight
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.2 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Storage Temp
    -20ºC
  • Shipping
    Gel Pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized powder
  • Physical form description
    Lyophilized
  • Reconstitution Instructions
    Reconstitute in sterile deionized water to a concentration of 50 ug/ml.
  • Background Information
    Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
  • Amino acid sequence
    AA Val 20 - Ser 503
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • About
    Rabbits are used for polyclonal antibody production by Biovision. Rabbit antibodies are very stable and can be stored for several days at room temperature. Biovision adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
  • Latin name
    Oryctolagus cuniculus
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    CellExp™   M-CSF   CSF1R   CD115  
  • Gene symbol
    CSF1, CSF1R, CPT1B, CSF2, IRAK3, PGAM2, CYP20A1, USP16, CYB5B, H3C14
  • Short name
    CellExp™ M-CSF R / CSF1R / CD115, Rabbit Recombinant
  • Technique
    Recombinant, Rabbit, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Host
    Rabbit, Rabbits
  • Species
    Humans
  • Alternative name
    H. sapiens CellExp™ M-CSF R / colony stimulating factor 1 receptor / CD115, production species: rabbit Rec.
  • Alternative technique
    rec, rabbit-anti
  • Alternative to gene target
    colony stimulating factor 1 receptor, C-FMS and CD115 and CSF-1R and CSFR and FIM2 and FMS and HDLS and M-CSF-R, CSF1R and IDBG-53268 and ENSG00000182578 and 1436, transferase activity, Cell surfaces, Csf1r and IDBG-150998 and ENSMUSG00000024621 and 12978, CSF1R and IDBG-646265 and ENSBTAG00000012771 and 509418
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    colony stimulating factor 1 receptor
  • Synonyms gene
  • Synonyms gene name
    • McDonough feline sarcoma viral (v-fms) oncogene homolog
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2001-06-22
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Immunoglobulin like domain containing
    • Receptor tyrosine kinases
    • CD molecules
  • VEGA ID
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    interleukin 1 receptor associated kinase 3
  • Synonyms gene name
    • interleukin-1 receptor-associated kinase 3
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2002-07-17
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • MicroRNA protein coding host genes
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    phosphoglycerate mutase 2
  • Synonyms gene name
    • phosphoglycerate mutase 2 (muscle)
  • Synonyms
  • Locus
  • Discovery year
    1989-06-30
  • Entrez gene record
  • Classification
    • Phosphoglycerate mutases
    • Bisphosphoglycerate phosphatases
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    cytochrome P450 family 20 subfamily A member 1
  • Synonyms gene name
    • cytochrome P450, family 20, subfamily A, polypeptide 1
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2003-03-20
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Cytochrome P450 family 20
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    ubiquitin specific peptidase 16
  • Synonyms gene name
    • ubiquitin specific protease 16
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1999-07-09
  • Pubmed identfication
  • Classification
    • Ubiquitin specific peptidases
  • VEGA ID
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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