Human CellExp™ CD319 / SLAMF7 / CRACC, human recombinant
-
Catalog number7376-50
-
PricePlease ask
-
Size50 ug
-
-
SynonymsSLAMF7, CD319, CS1, CRACC, 19A, FOAP-12
-
Alternative_namesSLAMF7, CD319, CS1, CRACC, 19A, FOAP-12
-
DescriptionMediates NK cell activation
-
RecombinantYes
-
SourceHEK293 cells
-
Purity by SDS PAGE≥95%
-
AssaySDS-PAGE
-
Biological activityMeasured by its ability to bind biotinylated human SLAMF7 in a functional ELISA.
-
ResultsMeasured by its ability to bind biotinylated human SLAMF7 in a functional ELISA.
-
Molecular WeightThis protein is fused with 6×His tag at the C-terminus, has a calculated MW of 23.2 kDa. The predicted N-terminus is Ser 23. DTT-reduced Protein migrates as 33-48 kDa due to glycosylation.
-
Storage Temp-20°C
-
ShippingGel Pack
-
Shelf Life12 months
-
AppearanceLyophilized
-
Physical form descriptionLyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
-
Reconstitution InstructionsCentrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
-
Background InformationSLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.
-
HandlingCentrifuge the vial prior to opening.
-
UsageFor Research Use Only! Not to be used in humans
-
PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Additional sourceRecombinants or rec. proteins
-
Grouprecombinants
-
Gene target
-
Gene symbolSLAMF7
-
Short nameCellExp™ CD319 / SLAMF7 / CRACC, recombinant
-
TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
SpeciesHumans
-
Alternative nameH. sapiens CellExp™ CD319 / SLAM family member 7 / CRACC, H. sapiens Rec.
-
Alternative techniquerec
-
Alternative to gene targetSLAM family member 7, SLAMF7 and IDBG-104088 and ENSG00000026751 and 57823, protein binding, Cell surfaces, Slamf7 and IDBG-204760 and ENSMUSG00000038179 and 75345, SLAMF7 and IDBG-630522 and ENSBTAG00000001197 and 790164
-
Gene info
-
Identity
-
Gene
-
Long gene nameSLAM family member 7
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2003-10-29
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- CD molecules
- V-set domain containing
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data