Human CellExp™ CD200/OX-2, human recombinant

  • Catalog number
    7384-10
  • Price
    Please ask
  • Size
    10 ug
  • Synonyms
    CD200, MOX1, MOX2, MRC, OX-2, My033
  • Alternative_names
    CD200, MOX1, MOX2, MRC, OX-2, My033
  • Description
    Involved in regulation of macrophage and mast cell function.
  • Recombinant
    Yes
  • Source
    HEK293 cells
  • Purity by SDS PAGE
    ≥98%
  • Assay
    SDS-PAGE
  • Biological activity
    Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD200R1 at 2 ug/ml. The concentration of rhCD200 that produces 50% of the optimal binding response is approximately 0.5‑16 ng/ml.
  • Results
    Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD200R1 at 2 ug/ml. The concentration of rhCD200 that produces 50% of the optimal binding response is approximately 0.5‑16 ng/ml.
  • Molecular Weight
    This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 23.4 kDa. The predicted N-terminus is Gln 31. DTT-reduced Protein migrates as 35-45 kDa due to glycosylation.
  • Storage Temp
    -20°C
  • Shipping
    Gel Pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized
  • Physical form description
    Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
  • Reconstitution Instructions
    Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
  • Background Information
    CD200 also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    CD200, HCRT, TNFSF4, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2, MIR329-2, RNU6-2
  • Short name
    CellExp™ CD200/OX-2, recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Humans
  • Alternative name
    H. sapiens CellExp™ CD200 molecule/OX-2, H. sapiens Rec.
  • Alternative technique
    rec
  • Alternative to gene target
    CD200 molecule, MOX1 and MOX2 and MRC and OX-2, CD200 and IDBG-49799 and ENSG00000091972 and 4345, protein binding, Plasma membranes, Cd200 and IDBG-162936 and ENSMUSG00000022661 and 17470, CD200 and IDBG-632279 and ENSBTAG00000033319 and 534910
Gene info
  • Identity
  • Gene
  • Long gene name
    CD200 molecule
  • Synonyms gene
  • Synonyms gene name
    • antigen identified by monoclonal antibody MRC OX-2
    • CD200 antigen
  • Synonyms
  • Locus
  • Discovery year
    2001-06-22
  • Entrez gene record
  • Classification
    • CD molecules
    • Immunoglobulin like domain containing
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    TNF superfamily member 4
  • Synonyms gene
  • Synonyms gene name
    • tax-transcriptionally activated glycoprotein 1, 34kD
    • tumor necrosis factor (ligand) superfamily, member 4
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1993-12-15
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Tumor necrosis factor superfamily
    • CD molecules
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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