Bax Antibody

• Catalog number
  A00183
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Bax
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human
• Analyses
  WB,IHC-P
• Immunogen
  A synthetic peptide corresponding to a sequence at the N-terminus of human Bax (17-48aa EQIMKTGALLLQGFIQDRAGRMGGEAPELALD), different from the related mouse and rat sequences by five amino acids.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Bax Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Bax Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. Additionally, this protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
• Related articles
  1. Apte, S. S.; Mattei, M.-G.; Olsen, B. R. : Mapping of human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX-delta. Genomics 26: 592-594, 1995. 2. Guo, B.; Zhai, D.; Cabezas, E.; Welsh, K.; Nouraini, S.; Satterthwait, A. C.; Reed, J. C. : Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature 423: 456-461, 2003. 3. Oltvai, Z. N.; Milliman, C. L.; Korsmeyer, S. J. : Bcl-2 heterodimers in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619, 1993. 4. Takeuchi, O.; Fisher, J.; Suh, H.; Harada, H.; Malynn, B. A.; Korsmeyer, S. J. : Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc. Nat. Acad. Sci. 102: 11272-11277, 2005.
• Gene Name
  BAX
• Protein Name
  Apoptosis regulator BAX
• Gene Full Name
  BCL2-associated X protein
• Synonyms
  Apoptosis regulator BAX | BAXA | Bcl2-L-4 | BCL2L4 | Bcl-2-like protein 4 | Q07812
• Uniprot ID
  Q07812
• Entrez GeneID
  581
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Bax  
• Gene symbol
  TMBIM7P, TMBIM6, TMBIM1
• Short name
  Bax Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  BCL2-associated X protein (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  BCL2-associated X protein, BCL2L4, BAX and IDBG-61459 and ENSG00000087088 and 581, BH3 domain binding, nuclei, Bax and IDBG-183241 and ENSMUSG00000003873 and 12028, BAX and IDBG-640344 and ENSBTAG00000013340 and 100850136,280730

Gene info

• Identity
  HGNC:49212
• Gene
  TMBIM7P
• Long gene name
  transmembrane BAX inhibitor motif containing 7, pseudogene
• Locus
  7q21.2
• Discovery year
  2013-10-09
• Entrez gene record
  105375396
• Classification
  • Transmembrane BAX inhibitor motif containing
• VEGA ID
  OTTHUMG00000155903

Gene info

• Identity
  HGNC:11723
• Gene
  TMBIM6
• Long gene name
  transmembrane BAX inhibitor motif containing 6
• Synonyms gene
  • TEGT
• Synonyms gene name
  • testis enhanced gene transcript
• Synonyms
  • BI-1
  • BAXI1
• Synonyms name
  • BAX inhibitor 1
• GenBank acession
  • X75861
• Locus
  12q13.12
• Discovery year
  1994-08-30
• Entrez gene record
  7009
• Pubmed identfication
  • 8530040
  • 9660918
• RefSeq identity
  • NM_003217
• Classification
  • Transmembrane BAX inhibitor motif containing
• VEGA ID
  OTTHUMG00000169652

Gene info

• Identity
  HGNC:23410
• Gene
  TMBIM1
• Long gene name
  transmembrane BAX inhibitor motif containing 1
• Synonyms
  • PP1201
  • RECS1
  • LFG3
• GenBank acession
  • BN000408
• Locus
  2q35
• Discovery year
  2005-08-22
• Entrez gene record
  64114
• Pubmed identfication
  • 28481357
• RefSeq identity
  • NM_022152
• Classification
  • Transmembrane BAX inhibitor motif containing
• VEGA ID
  OTTHUMG00000133105

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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