HAS1 Antibody

• Catalog number
  F48932-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  HAS1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the HAS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This HAS1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q92839
• Purity
  Antigen affinity
• Description
  Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.
• Immunogen
  A portion of amino acids 166-193 from the human protein was used as the immunogen for this HAS1 antibody.
• Storage
  Aliquot the HAS1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  HAS1  
• Gene symbol
  HAS1, DDX18, HNF1A-AS1
• Short name
  Anti-HAS1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to HAS1
• Alternative technique
  antibodies
• Alternative to gene target
  hyaluronan synthase 1, HAS, HAS1 and IDBG-66243 and ENSG00000105509 and 3036, hyaluronan synthase activity, Plasma membranes, Has1 and IDBG-141052 and ENSMUSG00000003665 and 15116, HAS1 and IDBG-641414 and ENSBTAG00000017672 and 101907856,282820

Gene info

• Identity
  HGNC:4818
• Gene
  HAS1
• Long gene name
  hyaluronan synthase 1
• Synonyms gene
  • HAS
• GenBank acession
  • U59269
• Locus
  19q13.41
• Discovery year
  1996-04-12
• Entrez gene record
  3036
• Pubmed identfication
  • 9169154
• RefSeq identity
  • NM_001523
• Classification
  • Glycosyltransferase family 2
• VEGA ID
  OTTHUMG00000183499

Gene info

• Identity
  HGNC:2741
• Gene
  DDX18
• Long gene name
  DEAD-box helicase 18
• Synonyms gene name
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18 (Myc-regulated)
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
• Synonyms
  • MrDb
  • Has1
• GenBank acession
  • X98743
• Locus
  2q14.1
• Discovery year
  1999-09-28
• Entrez gene record
  8886
• Pubmed identfication
  • 8861962
• RefSeq identity
  • NM_006773
• Classification
  • DEAD-box helicases
  • SSU processome
• VEGA ID
  OTTHUMG00000058521

Gene info

• Identity
  HGNC:26785
• Gene
  HNF1A-AS1
• Long gene name
  HNF1A antisense RNA 1
• Synonyms gene
  • C12orf27
  • NCRNA00262
• Synonyms gene name
  • chromosome 12 open reading frame 27
  • non-protein coding RNA 262
  • HNF1A antisense RNA 1 (non-protein coding)
• Synonyms
  • FLJ38690
  • HAS1
• GenBank acession
  • AK096009
• Locus
  12q24.31
• Discovery year
  2006-01-06
• Entrez gene record
  283460
• Pubmed identfication
  • 24000294
  • 25863539
  • 28943452
• RefSeq identity
  • NR_024345
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000185474

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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