HLA-DPB1 Polyclonal Antibody
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Catalog numberCAC07550
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PricePlease ask
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Size50 μg
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Other nameHLA class II histocompatibility antigen, DP(W4) beta chain,MHC class II antigen DPB1,HLA-DPB1,HLA-DP1B
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ImmunogenRecombinant human HLA class II histocompatibility antigen, DP beta 1 chain protein (30-225AA)
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Verified reactivityHuman
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Verified applicationsELISA,WB,IHC
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Raised inRabbit
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ClonalityPolyclonal
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Protein numberP04440
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Gene numberPlease refer to GenBank
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NCBI numberPlease refer to NCBI
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PurityCaprylic Acid Ammonium Sulfate Precipitation Purified
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Storage recommendationAliquot and store at -20°C. Minimize freezing and thawing.
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Use before1 year
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Shipping requirementsBlue ice
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Estimated production time3-7 business days
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Supplementary informationBinds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
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NotesFor research use only. Not for diagnostic procedures.
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PropertiesIf you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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GroupPolyclonals and antibodies
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AboutPolyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
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French translationanticorps
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Gene target
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Gene symbolHLA-DPB1, HLA-DPA2, HLA-DOA, HLA-DQA1, HLA-N, HLA-DQA2, HLA-DQB2, HLA-W, HLA-DRA, HLA-S
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Short nameHLA-DPB1 Polyclonal Antibody
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TechniquePolyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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LabelUnconjugated
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Alternative namemajor histocompatibility aggregate, class II, DP b 1 polyclonal (antibody to-)
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Alternative techniquepolyclonals, antibodies
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Alternative to gene targetmajor histocompatibility complex, class II, DP beta 1, DPB1 and HLA-DP and HLA-DP1B and HLA-DPB, HLA-DPB1 and IDBG-230487 and ENSG00000223865 and 3115, peptide antigen binding, Cell surfaces
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Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class II, DP beta 1
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Synonyms gene
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class II, DP alpha 2 (pseudogene)
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Synonyms gene
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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Classification
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class II, DO alpha
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
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VEGA ID
-
Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class II, DQ alpha 1
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Synonyms gene
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Synonyms
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class I, N (pseudogene)
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-10-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene namemajor histocompatibility complex, class II, DQ alpha 2
-
Synonyms gene
-
Locus
-
Discovery year2001-06-22
-
Entrez gene record
-
RefSeq identity
-
Classification
- C1-set domain containing
- Histocompatibility complex
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
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Long gene namemajor histocompatibility complex, class II, DQ beta 2
-
Synonyms gene
-
GenBank acession
-
Locus
-
Discovery year2001-06-22
-
Entrez gene record
-
Pubmed identfication
-
Classification
- C1-set domain containing
- Histocompatibility complex
-
VEGA ID
-
Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class I, W (pseudogene)
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Synonyms gene
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Synonyms gene name
- HLA-80 pseudogene
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GenBank acession
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Locus
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Discovery year2004-01-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class II, DR alpha
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Synonyms gene
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
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VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
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Long gene namemajor histocompatibility complex, class I, S (pseudogene)
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-10-23
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Entrez gene record
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Pubmed identfication
-
RefSeq identity
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Classification
- Histocompatibility complex
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VEGA ID
-
Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data