HFE/Hemochromatosis Antibody, ALEXA FLUOR 488

• Catalog number
  bs-12335R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  HFE/Hemochromatosis Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-HFE/Hemochromatosis PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  HFE/Hemochromatosis
• Specificity
  This is a highly specific antibody against HFE/Hemochromatosis.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HFE/Hemochromatosis
• Gene ID Number
  3077
• Tested applications
  FCM, IF(IHC-P)
• Recommended dilutions
  FCM(1:20-100), IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localization. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with β2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  dJ221C16.10.1; Hemochromatosis; Hemochromatosis protein; Hereditary hemochromatosis protein; Hereditary hemochromatosis protein HLA H; HFE 1; HFE; HFE_HUMAN; HFE1; HH; High Fe; HLA H; HLA-H; HLAH; MGC:150812; MGC10379; MGC103790; MHC class I like protein HFE; MVCD7; TFQTL2.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-HFE/Hemochromatosis has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  HFE/Hemochromatosis  
• Gene symbol
  HFE-AS1, HFE
• Short name
  Anti-HFE/Hemochromatosis
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  HFE/Hemochromatosis Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies
• Alternative to gene target
  hemochromatosis, HFE1 and HH and HLA-H and MVCD7 and TFQTL2, HFE and IDBG-67372 and ENSG00000010704 and 3077, peptide antigen binding, Plasma membranes, Hfe and IDBG-136751 and ENSMUSG00000006611 and 15216, BT.37142 and IDBG-635416 and ENSBTAG00000013065 and 497622

Gene info

• Identity
  HGNC:55168
• Gene
  HFE-AS1
• Long gene name
  HFE antisense RNA 1
• Locus
  6p22.2
• Discovery year
  2020-07-22
• Entrez gene record
  108783645
• RefSeq identity
  • NR_144383
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:4886
• Gene
  HFE
• Long gene name
  homeostatic iron regulator
• Synonyms gene name
  • hemochromatosis
• Synonyms
  • HLA-H
  • HFE1
• Synonyms name
  • high Fe
• Locus
  6p22.2
• Discovery year
  1986-01-01
• Entrez gene record
  3077
• Pubmed identfication
  • 3460331
  • 28474781
  • 9054933
• Classification
  • C1-set domain containing
• VEGA ID
  OTTHUMG00000016348
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_748

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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