HEXA/Beta hexosaminidase subunit alpha Antibody

• Catalog number
  bs-11726R
• Price
  Please ask
• Size
  0.1ml

• Long name
  HEXA/Beta hexosaminidase subunit alpha Antibody
• Also known as
  HEXA/Beta hexosaminidase subunit alpha Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  HEXA/Beta hexosaminidase subunit alpha
• Specificity
  This is a highly specific antibody against HEXA/Beta hexosaminidase subunit alpha.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Beta hexosaminidase subunit alpha
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Hexosaminidase A (HEXA), also designated beta-Hexosaminidase A, is a trimer composed of one å chain, one ∫-A chain and one ∫-B chain and is found in the lysosomes of cells. HEXA, along with the cofactor CM2 activator protein, catalyzes the degradation of GM2 ganglioside and other molecules containing terminal N-acetyl hexosamines in the brain and other tissues. A mutation in the å subunit of hexosaminidase is the cause of Tay-Sachs disease (TSD), also known as GM2-gangliosidosis type I. TSD is a fatal autosomal recessive lysosomal storage disease of the central nervous system (CNS) caused by insufficient activity of the HEXA enzyme that results in a failure to process GM2 gangliosides. The accumulation of GM2 ganglioside in the absence of HEXA activity causes progressive destruction of the CNS.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Beta hexosaminidase alpha chain precursor; Beta hexosaminidase subunit alpha; Beta N acetylhexosaminidase; Beta N acetylhexosaminidase subunit alpha; Beta-hexosaminidase subunit alpha; Beta-N-acetylhexosaminidase subunit alpha; Hexa; HEXA_HUMAN; Hexosaminidase A alpha polypeptide; Hexosaminidase A alpha polypeptide; Hexosaminidase A; Hexosaminidase subunit A; MGC99608; N acetyl beta glucosaminidase; N acetyl beta glucosaminidase subunit alpha; N-acetyl-beta-glucosaminidase subunit alpha; TSD.
• Description
  The Anti-HEXA/Beta hexosaminidase subunit alpha is a α- or alpha protein sometimes glycoprotein present in blood.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  HEXA/Beta   hexosaminidase   subunit   alpha  
• Gene symbol
  HEXA, HEXA-AS1
• Short name
  Anti-HEXA/Beta hexosaminidase subunit alpha
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  HEXA/Beta hexosaminidase subunit alpha Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4878
• Gene
  HEXA
• Long gene name
  hexosaminidase subunit alpha
• Synonyms gene name
  • hexosaminidase A (alpha polypeptide)
• Synonyms name
  • Tay Sachs disease
  • GM2 gangliosidosis
  • beta-hexosaminidase subunit alpha
• GenBank acession
  • M13520
• Locus
  15q23
• Discovery year
  2001-06-22
• Entrez gene record
  3073
• Pubmed identfication
  • 2952641
  • 3013851
• RefSeq identity
  • NM_000520
• Classification
  • Hexosaminidases
• VEGA ID
  OTTHUMG00000133445
• Locus Specific Databases
  • Hexosaminidase A; Tay-Sachs Disease
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Gene info

• Identity
  HGNC:25810
• Gene
  HEXA-AS1
• Long gene name
  HEXA antisense RNA 1
• Synonyms gene
  • C15orf34
• Synonyms gene name
  • chromosome 15 open reading frame 34
  • HEXA antisense RNA 1 (non-protein coding)
• Synonyms
  • FLJ13315
• Locus
  15q23
• Discovery year
  2005-10-20
• Entrez gene record
  80072
• Pubmed identfication
  • 12477932
• RefSeq identity
  • NR_027262
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000177184

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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