HES1 (7H11) Monoclonal Antibody
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Catalog number
bsm-50241M
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Price
Please ask
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Size
0.1ml
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Long name
HES1 (7H11) Monoclonal Antibody
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Also known as
HES1 (7H11) Monoclonal Antibody
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Category
Primary Antibodies
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Conjugation
Unconjugated
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Target Antigen
Hairy and Enhancer of Split 1
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Specificity
This is a highly specific antibody against Hairy and Enhancer of Split 1.
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Modification s
None
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Modification site s
Unmodified antibody
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Clonality
Monoclonal
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Clone number
7H11
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Concentration
1ug per 1ul
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Source
His-tagged recombinant human Hes1 protein purified from E.coli
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Swiss Prot
Q8IXV0
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Tested Applications
WB, IP
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Recommended dilutions
WB (1.0 ug/ml) IP (5.0 ug)
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Cross reactivity
Human
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigen
The Notch signaling pathway is important for cell-cell communication, which involve gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. It critically influences cell proliferation, differentiation, and apoptosis in metazoans. The hairy and enhancer of split (HES) family is a basic helix-loop-helix (bHLH) type trancriptional repressor and acts as Notch effectors by negatively regulating expression of downstream target genes such as tissue-specific transcription factors. HES-1 is an upstream negative regulator of REST expression. Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and β-cells. Recent integrative genomic analyses on HES/HEY family suggest that HES1 and HES3 are target genes of the embryonic stem cell-specific network of transcription factors, and that HES1, HES5, HEY1, HEY2 and HEYL are target genes of Notch signaling pathway.
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Purification method
Purified by Protein G.
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Storage conditions
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Properties
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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French translation
anticorps
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Gene target
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Gene symbol
HES1, GATD3
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Short name
Anti-Hairy and Enhancer of Split 1
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Technique
Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
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Host
Mouse (Mus musculus)
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Isotype
Immunoglobulin G (IgG)2b κ
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Alternative name
HES1 (7H11) Monoclonal Antibody
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Alternative technique
antibodies
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Alternative to gene target
hairy and enhancer of split 1, (Drosophila), bHLHb39 and HES-1 and HHL and HRY, HES1 and IDBG-70185 and ENSG00000114315 and 3280, N-box binding, nuclei, Hes1 and IDBG-151888 and ENSMUSG00000022528 and 15205, HES1 and IDBG-634294 and ENSBTAG00000000569 and 539547
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Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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