Heparan Sulfate Proteoglycan 2 Antibody
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Catalog numberbs-5072R
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PricePlease ask
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Size0.1ml
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Long nameHeparan Sulfate Proteoglycan 2 Antibody
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Also known asHeparan Sulfate Proteoglycan 2 Antibody
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenHeparan Sulfate Proteoglycan 2
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SpecificityThis is a highly specific antibody against Heparan Sulfate Proteoglycan 2.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Heparan Sulfate Proteoglycan 2
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Gene ID number117194
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Tested ApplicationsIHC-P, IF(IHC-P)
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Recommended dilutionsIHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenThis gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans(heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010].
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesPerlecan; Basement membrane specic heparan sulfate proteoglycan core protein; Endorepellin domain V region; Heparan Sulfate Proteoglycan; Heparan sulfate proteoglycan of basement membrane; HSPG 2; HSPG; Hspg2; LG3 peptide; Perlecan; PLC antibody Schwartz Jampel syndrome 1 chondrodystrophic myotonia; SJA antibody SJS antibody SJS1 antibody.
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolHSPG2, SDC2
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Short nameAnti-Heparan Sulfate Proteoglycan 2
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameHeparan Sulfate Proteoglycan 2 Antibody
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameheparan sulfate proteoglycan 2
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Synonyms gene
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Synonyms gene name
- Schwartz-Jampel syndrome 1 (chondrodystrophic myotonia)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-02-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- I-set domain containing
- Proteoglycans
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesyndecan 2
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Synonyms gene
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Synonyms gene name
- heparan sulfate proteoglycan 1, cell surface-associated
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1989-06-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Syndecans
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data