ACVR2B/ACTR-IIB Antibody, ALEXA FLUOR 594
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Catalog number
bs-12417R-A594
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Price
Please ask
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Size
100ul
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Long name
ACVR2B/ACTR-IIB Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
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Also known as
Anti-ACVR2B/ACTR-IIB PAb ALEXA FLUOR 594
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Category
Conjugated Primary Antibodies
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Conjugated with
ALEXA FLUOR® 594
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
ACVR2B/ACTR-IIB
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Specificity
This is a highly specific antibody against ACVR2B/ACTR-IIB.
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Modification
Unmodified
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Modification Site
None
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Immunogen range
50-100/512
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Subcellular location
Extracellular
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Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ACVR2B/ACTR-IIB
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Gene ID Number
93
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Swiss Prot
Q13705
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Tested applications
IF(IHC-P)
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Recommended dilutions
IF(IHC-P)(1:50-200)
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Crossreactivity
Human, Mouse, Rat
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigen
Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.
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Purification
Purified by Protein A.
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Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission
590nm/617nm
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Synonyms
HTX4; ACTRIIB; ActR-IIB; Activin receptor type-2B; Activin receptor type IIB; ACVR2B
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Properties
For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Conjugation
Alexa Fluor, ALEXA FLUOR® 594
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Conjugated
Alexa conjugate 1
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French translation
anticorps
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Gene target
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Gene symbol
ACVR2B, ACVR2B-AS1, MYH4, NCOA3
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Short name
Anti-ACVR2B/ACTR-IIB
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Immunoglobulin G (IgG)
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Label
ALEXA FLUOR 594
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Alternative name
ACVR2B/ACTR-IIB Polyclonal Antibody, ALEXA FLUOR 594
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Alternative technique
antibodies
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Gene info
Gene info
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Identity
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Gene
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Long gene name
ACVR2B antisense RNA 1
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Synonyms gene name
- ACVR2B antisense RNA 1 (non-protein coding)
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GenBank acession
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Locus
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Discovery year
2012-06-30
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Entrez gene record
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
myosin heavy chain 4
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Synonyms gene name
- myosin, heavy polypeptide 4, skeletal muscle
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Synonyms
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Locus
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Discovery year
1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Myosin heavy chains, class II
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VEGA ID
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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