HCN2 + HCN4 Antibody

• Catalog number
  bs-11630R
• Price
  Please ask
• Size
  0.1ml

• Long name
  HCN2 + HCN4 Primary Polyclonal Antibody
• Also known as
  HCN2 + HCN4 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  HCN2 + HCN4
• Specificity
  This is a highly specific antibody against HCN2 + HCN4.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HCN2 + HCN4
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Hyperpolarization activated cation channels of the HCN gene family such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. HCN4 is another member of the family of hyperpolarization activated and cyclic nucleotide gated channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  BCNG 2; Brain cyclic nucleotide gated channel 2; HAC 1; HCN 4; HCN 2; Hyperpolarization activated cyclic nucleotide gated potassium channel 4;HCN2_HUMAN; HCN4_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  HCN2   HCN4  
• Gene symbol
  HCN4, HCN2
• Short name
  Anti-HCN2 + HCN4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  HCN2 + HCN4 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:16882
• Gene
  HCN4
• Long gene name
  hyperpolarization activated cyclic nucleotide gated potassium channel 4
• Synonyms gene name
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 4
• GenBank acession
  • AJ132429
• Locus
  15q24.1
• Discovery year
  2002-09-02
• Entrez gene record
  10021
• Pubmed identfication
  • 10228147
  • 10430953
  • 16382102
• RefSeq identity
  • NM_005477
• Classification
  • Cyclic nucleotide gated channels
• VEGA ID
  OTTHUMG00000137563

Gene info

• Identity
  HGNC:4846
• Gene
  HCN2
• Long gene name
  hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
• Synonyms gene
  • BCNG2
• Synonyms gene name
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 2
  • hyperpolarization activated cyclic nucleotide gated potassium channel 2
• Synonyms
  • BCNG-2
  • HAC-1
• GenBank acession
  • AF064877
• Locus
  19p13.3
• Discovery year
  1998-08-20
• Entrez gene record
  610
• Pubmed identfication
  • 9405696
  • 9630217
  • 16382102
  • 10228147
  • 19584315
• RefSeq identity
  • NM_001194
• Classification
  • Cyclic nucleotide gated channels
• VEGA ID
  OTTHUMG00000180590

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products