HELT Antibody

• Catalog number
  bs-11851R
• Price
  Please ask
• Size
  0.1ml

• Long name
  HELT Primary Polyclonal Antibody
• Also known as
  HELT PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  HELT
• Specificity
  This is a highly specific antibody against HELT.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HELT
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The Notch signaling pathway is thought to maintain stem cells through transcriptional activation of HES/HEY family members to repress tissue-specific transcription factors. HESL (HES-like), also known as Mgn or HELT (HES/HEY-like transcription factor), is a 327 amino acid nuclear protein belonging to the HEY family. Containing a basic helix-loop-helix (bHLH) domain and an Orange domain, HESL self-associates and interacts with HES5 and HRT2. HESL is considered a transcriptional repressor that binds to the canonical E box sequence 5'-CACGCG-3'. HESL exists as two isoforms produced by alternative splicing events.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Hairy and enhancer of split-related protein HELT; HCM1228; HELT; HELT_HUMAN; HES like ; HES/HEY like transcription factor; HES/HEY-like transcription factor; HESL; Heslike ; Hey like transcription factor; Hey like transcription factor zebrafish; Hey like transcriptional repressor; Megane bHLH factor; Mgn.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  HELT  
• Gene symbol
  HELT
• Short name
  Anti-HELT
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  HELT Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:33783
• Gene
  HELT
• Long gene name
  helt bHLH transcription factor
• Synonyms gene name
  • Hey-like transcription factor (zebrafish)
  • HES/HEY-like transcription factor
• Synonyms
  • HESL
  • HCM1228
  • Mgn
  • bHLHb44
  • MEGANE
• Synonyms name
  • megane bHLH factor
  • HES-like
• GenBank acession
  • BC144567
• Locus
  4q35.1
• Discovery year
  2008-04-21
• Entrez gene record
  391723
• Pubmed identfication
  • 14764602
  • 17611227
• RefSeq identity
  • NM_001300781
• Classification
  • Basic helix-loop-helix proteins
• VEGA ID
  OTTHUMG00000160484

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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