Cortactin Antibody

• Catalog number
  bs-50538R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Cortactin Primary Polyclonal Antibody
• Also known as
  Cortactin PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Cortactin
• Specificity
  This is a highly specific antibody against Cortactin.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  Synthetic peptide
• Gene ID number
  2017
• Swiss Prot
  Q14247
• Tested Applications
  WB
• Recommended dilutions
  WB (1:5,000)
• Cross reactivity
  Human, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1; CTTN
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Cortactin  
• Gene symbol
  CTTNBP2, HCLS1, CTTN
• Short name
  Anti-Cortactin
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Cortactin Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:15679
• Gene
  CTTNBP2
• Long gene name
  cortactin binding protein 2
• Synonyms gene
  • CORTBP2
  • C7orf8
• Synonyms gene name
  • CORTBP2, C7orf8
• Synonyms
  • KIAA1758
  • Orf4
• Locus
  7q31.31
• Discovery year
  2001-05-09
• Entrez gene record
  83992
• Pubmed identfication
  • 11707066
• RefSeq identity
  • NM_033427
• Classification
  • Ankyrin repeat domain containing
  • STRIPAK complex
• VEGA ID
  OTTHUMG00000022880

Gene info

• Identity
  HGNC:4844
• Gene
  HCLS1
• Long gene name
  hematopoietic cell-specific Lyn substrate 1
• Synonyms
  • HS1
  • CTTNL
• Synonyms name
  • cortactin-like
• Locus
  3q13.33
• Discovery year
  1995-09-26
• Entrez gene record
  3059
• Pubmed identfication
  • 8978766
  • 15710041
• RefSeq identity
  • NM_005335
• VEGA ID
  OTTHUMG00000159409

Gene info

• Identity
  HGNC:3338
• Gene
  CTTN
• Long gene name
  cortactin
• Synonyms gene
  • EMS1
• Synonyms gene name
  • ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
• GenBank acession
  • AJ288897
• Locus
  11q13.3
• Discovery year
  1994-01-07
• Entrez gene record
  2017
• Pubmed identfication
  • 7685625
• RefSeq identity
  • NM_138565
• VEGA ID
  OTTHUMG00000134307

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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