HCK, Active

• Catalog number
  7720-5
• Price
  Please ask
• Size
  5 ug

• Synonyms
  HCK, Tyrosine-protein kinase
• Alternative_names
  HCK, Tyrosine-protein kinase, Hematopoietic cell kinase, Hemopoietic cell kinase, p59-HCK/p60-HCK, p59Hck, p61Hck
• Description
  Plays a role in neutrophil migration
• Recombinant
  Yes
• Source
  Baculovirus (Sf9 insect cells)
• Purity by SDS PAGE
  ≥90%
• Assay
  SDS-PAGE
• Activity Specifications test method
  171 nmol phosphate incorporated into poly(Glu-Tyr) per minute per mg protein at 30°C for 15 minutes using a final concentration of 50 µM ATP (0.83 µCi/assay).
• Molecular Weight
  57.0 kDa
• Storage Temp
  -80°C
• Shipping
  dry ice
• Shelf Life
  12 months
• Concentration
  5µg/50 µl
• Appearance
  Liquid
• Physical form description
  Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
• Background Information
  HCK, a protein-tyrosine kinase, belongs to SRC family members (1). Ziegler et al. found that expression of HCK may be limited to certain hemopoietic cells and is especially prominent in cells of myeloid lineage, particularly mature granulocytes and monocytes (2). Therefore, Quintrell et al. designated the gene HCK (pronounced 'hick') for hemopoietic cell kinase. They described the nucleotide sequence of a cDNA clone and the distribution of RNA transcribed from HCK among various hemopoietic cells. They assigned the HCK gene to 20q11-q12. Since this region is affected by interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders, they suggested that damage to HCK may contribute to the pathogenesis of these conditions (3).
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet

• Gene target
  HCK   Active  
• Gene symbol
  HCK
• Short name
  HCK, Active
• Alternative name
  hemopoietic cell kinase, functionnal
• Alternative to gene target
  hemopoietic cell kinase, JTK9 and p59Hck and p61Hck, HCK and IDBG-64463 and ENSG00000101336 and 3055, transferase activity, nuclei, Hck and IDBG-209984 and ENSMUSG00000003283 and 15162, BT.44996 and IDBG-641612 and ENSBTAG00000007932 and 280814

Gene info

• Identity
  HGNC:4840
• Gene
  HCK
• Long gene name
  HCK proto-oncogene, Src family tyrosine kinase
• Synonyms gene name
  • hemopoietic cell kinase
• Synonyms
  • JTK9
• GenBank acession
  • AK026432
• Locus
  20q11.21
• Discovery year
  1986-01-01
• Entrez gene record
  3055
• Pubmed identfication
  • 3496523
• Classification
  • Src family tyrosine kinases
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000032204

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