HC Toxin

Alternative_name

(6R,9S,14aR)-3,6R-dimethyl-9S-(6-((S)-oxiran-2-yl)-6-oxohexyl)decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetranone; Toxin I (Helminthosporium carbonum)
Description

HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. It is a reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells
CAS Number

83209-65-8
Structure Available

Y
Salt Form

No
Molecular Formula

C₂₁H₃₂N₄O₆
Molecular Weight

436.5
Cell Permeable

Yes
Purity

≥95%
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A histone deacetylase (HDAC) inhibitor
Storage Condition

-20°C
Shipping Condition

Gel pack
Shelf Life

36 months
MDL Number

MFCD00133388
PubChem CID

23724535
PubChem CID Link
SMILES

O=C(C1CO1)CCCCC[C@@H](C(N2[C@]3([H])CCC2)=O)NC([C@@H](C)NC([C@H](C)NC3=O)=O)=O
InChi

InChI=1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14-,15+,17?/m0/s1
InChi Key

GNYCTMYOHGBSBI-KVUCBBCISA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:2092
Gene

CLTC
Long gene name

clathrin heavy chain
Synonyms gene
- CLTCL2
Synonyms gene name
- clathrin, heavy polypeptide (Hc)
- clathrin, heavy chain
- clathrin, heavy polypeptide-like 2
- clathrin, heavy chain (Hc)
Synonyms
- Hc
GenBank acession
- X55878
Locus

17q23.1
Discovery year

1990-10-16
Entrez gene record

1213
Pubmed identfication
- 1765375
- 7584026
RefSeq identity
- NM_004859
Classification
- Clathrin subunits
VEGA ID

OTTHUMG00000134279