Haptoglobin, Human Plasma (Mixed Type)

• Catalog number
  7535-1
• Price
  Please ask
• Size
  1 mg

• Synonyms
  Haptoglobin b-Chain, haptoglobin a-chain; Hp; Bp
• Alternative_names
  Haptoglobin b-Chain, haptoglobin a-chain; Hp; Bp
• Description
  An acute-phase plasma protein, which binds hemoglobin and prevents loss of iron through the kidneys
• Recombinant
  No
• Source
  Human Plasma
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Molecular Weight
  Hp 1-1: 86 kDa; Hp 2-1: 200 kDa; Hp 2-2: 400 kDa
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized as a salt-free solid.
• Background Information
  An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

• Gene target
  Haptoglobin   Plasma   Mixed  
• Short name
  Haptoglobin, Plasma (Mixed )
• Species
  Human, Humans
• Alternative name
  Haptoglobin, H. sapiens Plasma (Mixed classification)

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